Recombinant Melanocyte-stimulating hormone receptor (Mc1r); Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 8; NC_000074.6 (123407082..123410744). Location: 8 E1; 8 72.1 cM

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Mc1r recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Melanocyte-stimulating hormone receptor

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MSHR_MOUSE

MC1R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Cellular Component: membrane; plasma membrane; integral to membrane; intracellular

Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; melanocortin receptor activity; hormone binding; melanocyte stimulating hormone receptor activity; ubiquitin protein ligase binding

Biological Process: melanin biosynthetic process; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; pigmentation; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; sensory perception of pain; signal transduction

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