Product Name
Melanocyte-stimulating hormone receptor (MC1R), Recombinant Protein
Full Product Name
Recombinant Dog Melanocyte-stimulating hormone receptor (MC1R)
Product Synonym Names
Recombinant Melanocyte-stimulating hormone receptor (MC1R); Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R
Product Gene Name
MC1R recombinant protein
[Similar Products]
Product Synonym Gene Name
MC1R[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MVWQGPQRRL LGSLNGTSPA TPHFELAANQ TGPRCLEVSI PNGLFLSLGL VSVVENVLVV AAIAKNRNLH SPMYYFIGCL AVSDLLVSVT NVLETAVMLL VEAGALAAQA AVVQQLDDII DVLICGSMVS SLCFLGAIAV DRYLSIFYAL RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYNHTAVLL CLVSFFVAML VLMAVLYVHM LARARQHARG IARLRKRQHS VHQGFGLKGA ATLTILLGIF FLCWGPFFLH LSLMVLCPQH PICGCVFQNF NLFLTLIICN SIIDPFIYAF RSQELRKTLQ EVVLCSW
Chromosome Location
Chromosome: 5; NC_006587.3 (63694296..63695247, complement). Location: chromosome: 5
3D Structure
ModBase 3D Structure for O77616
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Canis familiaris (Dog) (Canis lupus familiaris)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MC1R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MC1R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001014304.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001014282.1
[Other Products]
UniProt Primary Accession #
O77616
[Other Products]
UniProt Related Accession #
O77616[Other Products]
Molecular Weight
34,984 Da[Similar Products]
NCBI Official Full Name
melanocyte-stimulating hormone receptor
NCBI Official Symbol
MC1R??[Similar Products]
NCBI Official Synonym Symbols
MC1-R; MSH-R
??[Similar Products]
NCBI Protein Information
melanocyte-stimulating hormone receptor; melanocortin receptor 1
UniProt Protein Name
Melanocyte-stimulating hormone receptor
UniProt Synonym Protein Names
Melanocortin receptor 1
Protein Family
Melanocyte-stimulating hormone receptor
UniProt Gene Name
MC1R??[Similar Products]
UniProt Synonym Gene Names
MSH-R; MC1-R??[Similar Products]
UniProt Entry Name
MSHR_CANFA
UniProt Comments for MC1R
Function: Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis.
Subunit structure: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on MC1R
1. 2 key mutations in the MC1R gene and the CBD103 gene are associated with the phenotypic discriminations among brindle, red/sesame, and white coats.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
