Product Name
tau tubulin kinase 2 (TTBK2), Polyclonal Antibody
Full Product Name
Rabbit anti-human tau tubulin kinase 2 polyclonal Antibody
Product Synonym Names
tau tubulin kinase 2; TTBK2; KIAA0847; SCA11; TTBK
Product Gene Name
anti-TTBK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165430
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TTBK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TTBK2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for TTBK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775771.3
[Other Products]
NCBI GenBank Nucleotide #
NM_173500.3
[Other Products]
UniProt Secondary Accession #
O94932; Q6ZN52; Q8IVV1[Other Products]
UniProt Related Accession #
Q6IQ55[Other Products]
Molecular Weight
54,037 Da[Similar Products]
NCBI Official Full Name
tau-tubulin kinase 2
NCBI Official Synonym Full Names
tau tubulin kinase 2
NCBI Official Symbol
TTBK2??[Similar Products]
NCBI Official Synonym Symbols
TTBK; SCA11
??[Similar Products]
NCBI Protein Information
tau-tubulin kinase 2
UniProt Protein Name
Tau-tubulin kinase 2
Protein Family
Tau-tubulin kinase
UniProt Gene Name
TTBK2??[Similar Products]
UniProt Synonym Gene Names
KIAA0847??[Similar Products]
UniProt Entry Name
TTBK2_HUMAN
NCBI Summary for TTBK2
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
UniProt Comments for TTBK2
TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; Kinase, protein; CK1 group; TTBK family
Chromosomal Location of Human Ortholog: 15q15.2
Cellular Component: centriole; extracellular space; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: regulation of cell shape; smoothened signaling pathway; peptidyl-serine phosphorylation; organelle organization and biogenesis; cilium biogenesis
Disease: Spinocerebellar Ataxia 11
Research Articles on TTBK2
1. data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages
Precautions
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Disclaimer
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