Product Name
C5, cDNA Clone
Full Product Name
C5 cDNA Clone
Product Gene Name
C5 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggccttt tgggaatact ttgtttttta atcttcctgg ggaaaacctg gggacaggag caaacatatg tcatttcagc accaaaaata ttccgtgttg gagcatctga aaatattgtg attcaagttt atggatacac tgaagcattt gatgcaacaa tctctattaa aagttatcct gataaaaaat ttagttactc ctcaggccat gttcatttat cctcagagaa taaattccaa aactctgcaa tcttaacaat acaaccaaaa caattgcctg gaggacaaaa cccagtttct tatgtgtatt tggaagttgt atcaaagcat ttttcaaaat caaaaagaat gccaataacc tatgacaatg gatttctctt cattcataca gacaaacctg tttatactcc agaccagtca gtaaaagtta gagtttattc gttgaatgac gacttgaagc cagccaaaag agaaactgtc ttaactttca tagatcctga aggatcagaa gttgacatgg tagaagaaat tgatcatatt ggaattatct cttttcctga cttcaagatt ccgtctaatc ctagatatgg tatgtggacg atcaaggcta aatataaaga ggacttttca acaactggaa ccgcatattt tgaagttaaa gaatatgtct tgccacattt ttctgtctca atcgagccag aatataattt cattggttac aagaacttta agaattttga aattactata aaagcaagat atttttataa taaagtagtc actgaggctg acgtttatat cacatttgga ataagagaag acttaaaaga tgatcaaaaa gaaatgatgc aaacagcaat gcaaaacaca atgttgataa atggaattgc tcaagtcaca tttgattctg aaacagcagt caaagaactg tcatactaca gtttagaaga tttaaacaac aagtaccttt atattgctgt aacagtcata gagtctacag gtggattttc tgaagaggca gaaatacctg gcatcaaata tgtcctctct ccctacaaac tgaatttggt tgctactcct cttttcctga agcctgggat tccatatccc atcaaggtgc aggttaaaga ttcgcttgac cagttggtag gaggagtccc agtaacactg aatgcacaaa caattgatgt aaaccaagag acatctgact tggatccaag caaaagtgta acacgtgttg atgatggagt agcttccttt gtgcttaatc tcccatctgg agtgacggtg ctggagttta atgtcaaaac tgatgctcca gatcttccag aagaaaatca ggccagggaa ggttaccgag caatagcata ctcatctctc agccaaagtt acctttatat tgattggact gataaccata aggctttgct agtgggagaa catctgaata ttattgttac ccccaaaagc ccatatattg acaaaataac tcactataat tacttgattt tatccaaggg caaaattatc cactttggca cgagggagaa attttcagat gcatcttatc aaagtataaa cattccagta acacagaaca tggttccttc atcccgactt ctggtctatt atatcgtcac aggagaacag acagcagaat tagtgtctga ttcagtctgg ttaaatattg aagaaaaatg tggcaaccag ctccaggttc atctgtctcc tgatgcagat gcatattctc caggccaaac tgtgtctctt aatatggcaa ctggaatgga ttcctgggtg gcattagcag cagtggacag tgctgtgtat ggagtccaaa gaggagccaa aaagcccttg gaaagagtat ttcaattctt agagaagagt gatctgggct gtggggcagg tggtggcctc aacaatgcca atgtgttcca cctagctgga cttaccttcc tcactaatgc aaatgcagat gactcccaag aaaatgatga accttgtaaa gaaattctca ggccaagaag aacgctgcaa aagaagatag aagaaatagc tgctaaatat aaacattcag tagtgaagaa atgttgttac gatggagcct gcgttaataa tgatgaaacc tgtgagcagc gagctgcacg gattagttta gggccaagat gcatcaaagc tttcactgaa tgttgtgtcg tcgcaagcca gctccgtgct aatatctctc ataaagacat gcaattggga aggctacaca tgaagaccct gttaccagta agcaagccag aaattcggag ttattttcca gaaagctggt tgtgggaagt tcatcttgtt cccagaagaa aacagttgca gtttgcccta cctgattctc taaccacctg ggaaattcaa ggcattggca tttcaaacac tggtatatgt gttgctgata ctgtcaaggc aaaggtgttc aaagatgtct tcctggaaat gaatatacca tattctgttg tacgaggaga acagatccaa ttgaaaggaa ctgtttacaa ctataggact tctgggatgc agttctgtgt taaaatgtct gctgtggagg gaatctgcac ttcggaaagc ccagtcattg atcatcaggg cacaaagtcc tccaaatgtg tgcgccagaa agtagagggc tcctccagtc acttggtgac attcactgtg cttcctctgg aaattggcct tcacaacatc aatttttcac tggagacttg gtttggaaaa gaaatcttag taaaaacatt acgagtggtg ccagaaggtg tcaaaaggga aagctattct ggtgttactt tggatcctag gggtatttat ggtaccatta gcagacgaaa ggagttccca tacaggatac ccttagattt ggtccccaaa acagaaatca aaaggatttt gagtgtaaaa ggactgcttg taggtgagat cttgtctgca gttctaagtc aggaaggcat caatatccta acccacctcc ccaaagggag tgcagaggcg gagctgatga gcgttgtccc agtattctat gtttttcact acctggaaac aggaaatcat tggaacattt ttcattctga cccattaatt gaaaagcaga aactgaagaa aaaattaaaa gaagggatgt tgagcattat gtcctacaga aatgctgact actcttacag tgtgtggaag ggtggaagtg ctagcacttg gttaacagct tttgctttaa gagtacttgg acaagtaaat aaatacgtag agcagaacca aaattcaatt tgtaattctt tattgtggct agttgagaat tatcaattag ataatggatc tttcaaggaa aattcacagt atcaaccaat aaaattacag ggtaccttgc ctgttgaagc ccgagagaac agcttatatc ttacagcctt tactgtgatt ggaattagaa aggctttcga tatatgcccc ctggtgaaaa tcgacacagc tctaattaaa gctgacaact ttctgcttga aaatacactg ccagcccaga gcacctttac attggccatt tctgcgtatg ctctttccct gggagataaa actcacccac agtttcgttc aattgtttca gctttgaaga gagaagcttt ggttaaaggt aatccaccca tttatcgttt ttggaaagac aatcttcagc ataaagacag ctctgtacct aacactggta cggcacgtat ggtagaaaca actgcctatg ctttactcac cagtctgaac ttgaaagata taaattatgt taacccagtc atcaaatggc tatcagaaga gcagaggtat ggaggtggct tttattcaac ccaggacaca atcaatgcca ttgagggcct gacggaatat tcactcctgg ttaaacaact ccgcttgagt atggacatcg atgtttctta caagcataaa ggtgccttac ataattataa aatgacagac aagaatttcc ttgggaggcc agtagaggtg cttctcaatg atgacctcat tgtcagtaca ggatttggca gtggcttggc tacagtacat gtaacaactg tagttcacaa aaccagtacc tctgaggaag tttgcagctt ttatttgaaa atcgatactc aggatattga agcatcccac tacagaggct acggaaactc tgattacaaa cgcatagtag catgtgccag ctacaagccc agcagggaag aatcatcatc tggatcctct catgcggtga tggacatctc cttgcctact ggaatcagtg caaatgaaga agacttaaaa gcccttgtgg aaggggtgga tcaactattc actgattacc aaatcaaaga tggacatgtt attctgcaac tgaattcgat tccctccagt gatttccttt gtgtacgatt ccggatattt gaactctttg aagttgggtt tctcagtcct gccactttca cagtgtacga ataccacaga ccagataaac agtgtaccat gttttatagc acttccaata tcaaaattca gaaagtctgt gaaggagccg cgtgcaagtg tgtagaagct gattgtgggc aaatgcagga agaattggat ctgacaatct ctgcagagac aagaaaacaa acagcatgta aaccagagat tgcatatgct tataaagtta gcatcacatc catcactgta gaaaatgttt ttgtcaagta caaggcaacc cttctggata tctacaaaac tggggaagct gttgctgaga aagactctga gattaccttc attaaaaagg taacctgtac taacgctgag ctggtaaaag gaagacagta cttaattatg ggtaaagaag ccctccagat aaaatacaat ttcagtttca ggtacatcta ccctttagat tccttgacct ggattgaata ctggcctaga gacacaacat gttcatcgtg tcaagcattt ttagctaatt tagatgaatt tgccgaagat atctttttaa atggatgcta a
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of C5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
NCBI Accession #
BC113738
[Other Products]
UniProt Secondary Accession #
Q14CJ0; Q27I61[Other Products]
UniProt Related Accession #
P01031[Other Products]
Molecular Weight
188,305 Da
NCBI Official Full Name
Homo sapiens complement component 5, mRNA
NCBI Official Synonym Full Names
complement C5
NCBI Official Symbol
C5??[Similar Products]
NCBI Official Synonym Symbols
C5D; C5a; C5b; ECLZB; CPAMD4
??[Similar Products]
NCBI Protein Information
complement C5
UniProt Protein Name
Complement C5
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Protein Family
C5a peptidase
UniProt Gene Name
C5??[Similar Products]
UniProt Synonym Gene Names
CPAMD4??[Similar Products]
UniProt Entry Name
CO5_HUMAN
NCBI Summary for C5
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
UniProt Comments for C5
C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33-q34
Cellular Component: extracellular region
Molecular Function: chemokine activity; protein binding; receptor binding
Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; chemotaxis; complement activation; G-protein coupled receptor protein signaling pathway; regulation of complement activation; response to stress
Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
Research Articles on C5
1. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 production)
Precautions
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Disclaimer
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