Chromobox protein homolog 2; CBX2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a component of the polycomb multiprotein
complex, which is required to maintain the transcriptionally
repressive state of many genes throughout development via chromatin
remodeling and modification of histones. Disruption of this gene in
mice results in male-to-female gonadal sex reversal. Mutations in
this gene are also associated with gonadal dysgenesis in humans.
Alternatively spliced transcript variants encoding different
isoforms have been noted for this gene.

Western Blot (WB), ELISA (EIA)

WB~~1:1000

CBX2 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CBX2 antibody detected the CBX2 protein (arrow).

56081

chromobox homolog 2

chromobox protein homolog 2

Chromobox protein homolog 2

CBX2_HUMAN

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]

CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; heterochromatin; euchromatin; PcG protein complex; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding; methylated histone residue binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; cell differentiation; development of primary sexual characteristics

Disease: 46,xy Sex Reversal 5

Biason-Lauber, A., et al. Am. J. Hum. Genet. 84(5):658-663(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Agrawal, N., et al. PLoS ONE 3 (12), E4032 (2008) :
Garcia, E., et al. EMBO J. 18(12):3404-3418(1999)
Katoh-Fukui, Y., et al. Nature 393(6686):688-692(1998)

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