Full Product Name
CBX2 antibody - middle region
Product Gene Name
anti-CBX2 antibody
[Similar Products]
Product Synonym Gene Name
CDCA6; M33; MGC10561; SRXY5[Similar Products]
Antibody/Peptide Pairs
CBX2 peptide (MBS3238799) is used for blocking the activity of CBX2 antibody (MBS3213861)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: SDSDPDSASP PSTGQNPSVS VQTSQDWKPT RSLIEHVFVT DVTANLITVT
3D Structure
ModBase 3D Structure for Q14781
Species Reactivity
Cow, Horse, Human, Pig, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 86%; Horse: 93%; Human: 100%; Pig: 79%; Rat: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CBX2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBX2 antibody
This is a rabbit polyclonal antibody against CBX2. It was validated on Western Blot
Target Description: CBX2 Contains 1 A.T hook DNA-binding domain and 1 chromo domain. CBX2 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Product Categories/Family for anti-CBX2 antibody
Polyclonal; Transcription Factor; Transcription Regulation; Cell Biology; Chromatin & Nuclear Signaling; Developmental Biology; Signal Transduction; Epigenetics; E3 & Ubiquitin; Membrane & Traffic; DNA/RNA/Protein Interactions; Transcription Factors; Cell
Applications Tested/Suitable for anti-CBX2 antibody
Western Blot (WB)
Western Blot (WB) of anti-CBX2 antibody
WB Suggested Anti-CBX2 Antibody Titration: 0.2-1 ug/ml
Positive Control: OVCAR-3 cell lysateCBX2 is supported by BioGPS gene expression data to be expressed in OVCAR3
NCBI/Uniprot data below describe general gene information for CBX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005180
[Other Products]
NCBI GenBank Nucleotide #
NM_005189
[Other Products]
UniProt Primary Accession #
Q14781
[Other Products]
UniProt Related Accession #
Q14781[Other Products]
NCBI Official Full Name
chromobox protein homolog 2 isoform 1
NCBI Official Synonym Full Names
chromobox 2
NCBI Official Symbol
CBX2??[Similar Products]
NCBI Official Synonym Symbols
M33; CDCA6; SRXY5
??[Similar Products]
NCBI Protein Information
chromobox protein homolog 2
UniProt Protein Name
Chromobox protein homolog 2
Protein Family
Chromobox protein
UniProt Gene Name
CBX2??[Similar Products]
UniProt Entry Name
CBX2_HUMAN
NCBI Summary for CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
Research Articles on CBX2
1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
