Full Product Name
CBX2 Antibody
Product Synonym Names
chromobox homolog 2, M33, CDCA6, SRXY5
Product Gene Name
anti-CBX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous level of total CBX2 protein.
Form/Format
Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Immunogen Type
Recombinant protein
Immunogen Description
Full length fusion protein
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBX2 antibody
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Product Categories/Family for anti-CBX2 antibody
Total protein Ab
Applications Tested/Suitable for anti-CBX2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CBX2 antibody
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000
Testing Data of anti-CBX2 antibody
Gel: 12+10%SDS-PAGELane1: Human ovarian cancer tissue lysateLane2: Mouse heart tissue lysateLysates: 30ug per lanePrimary antibody: 1/350 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutionExposure time: 20 seconds
NCBI/Uniprot data below describe general gene information for CBX2. It may not necessarily be applicable to this product.
NCBI Accession #
BC004252
[Other Products]
UniProt Secondary Accession #
Q0VDA5; Q9BTB1[Other Products]
UniProt Related Accession #
Q14781[Other Products]
Molecular Weight
23,312 Da
NCBI Official Full Name
Homo sapiens chromobox homolog 2 (Pc class homolog, Drosophila), mRNA
NCBI Official Synonym Full Names
chromobox homolog 2
NCBI Official Symbol
CBX2??[Similar Products]
NCBI Official Synonym Symbols
M33; CDCA6; SRXY5
??[Similar Products]
NCBI Protein Information
chromobox protein homolog 2
UniProt Protein Name
Chromobox protein homolog 2
Protein Family
Chromobox protein
UniProt Gene Name
CBX2??[Similar Products]
UniProt Entry Name
CBX2_HUMAN
NCBI Summary for CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for CBX2
CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; heterochromatin; euchromatin; PcG protein complex; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; development of primary sexual characteristics
Disease: 46,xy Sex Reversal 5
Research Articles on CBX2
1. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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