Mouse Monoclonal [clone 557] (IgG2a) to Human Complement C5; C5; Anaphylatoxin C5a analog; CPAMD4; Complement C5; Complement component 5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Sheep

Human Complement C5

Immunoaffinity Purified

10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2, 0.05% sodium azide.

Store at 2 degree C to 8 degree C.

Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient for C6. The C5b-C6 complex isthe foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediatorof local inflammatory process.

ELISA (EIA), Flow Cytometry (FC/FACS), Immunodiffusion (ID), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)

IHC-P: 10 ug/ml

Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

188,305 Da

complement C5

complement C5

Complement C5

CPAMD4??[Similar Products]

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

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