Full Product Name
CBX2 polyclonal antibody
Product Synonym Names
CDCA6; M33; SRXY5
Product Gene Name
anti-CBX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14781
Form/Format
In PBS with 0.05% (W/V) sodium azide.
Appearance: Colorless liquid
Immunogen
Polyclonal antibody raised in rabbit against mouse CBX2 (chromobox homolog 2) using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein.
Positive Control
ELISA: Peptides.
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBX2 antibody
Polyclonal Antibody to detect CBX2 in mouse samples.
Background: CBX2 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodelling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. CBX2 also is involved in sexual development, acting as an activator of NR5A1 expression.
Product Categories/Family for anti-CBX2 antibody
Epigenetics; Other Epigenetics Products; Antibodies & Blocking PeptidesEpigenetics; Writer Enzymes; DNA Methyltransferases (DNMTs); Antibodies and Blocking PeptidesAntibodies & Supporting Tools; Antibodies for Epigenetics ResearchAntibodies & Supporting T
Applications Tested/Suitable for anti-CBX2 antibody
ELISA (EIA)
Application Notes for anti-CBX2 antibody
ELISA: 1:300.
Testing Data of anti-CBX2 antibody
NCBI/Uniprot data below describe general gene information for CBX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005180.1
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NCBI GenBank Nucleotide #
NM_005189.2
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UniProt Primary Accession #
Q14781
[Other Products]
UniProt Secondary Accession #
Q0VDA5; Q9BTB1[Other Products]
UniProt Related Accession #
Q14781[Other Products]
Molecular Weight
23,312 Da
NCBI Official Full Name
chromobox protein homolog 2 isoform 1
NCBI Official Synonym Full Names
chromobox homolog 2
NCBI Official Symbol
CBX2??[Similar Products]
NCBI Official Synonym Symbols
M33; CDCA6; SRXY5
??[Similar Products]
NCBI Protein Information
chromobox protein homolog 2
UniProt Protein Name
Chromobox protein homolog 2
Protein Family
Chromobox protein
UniProt Gene Name
CBX2??[Similar Products]
UniProt Entry Name
CBX2_HUMAN
NCBI Summary for CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for CBX2
CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; heterochromatin; euchromatin; PcG protein complex; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; cell differentiation; development of primary sexual characteristics
Disease: 46,xy Sex Reversal 5
Research Articles on CBX2
1. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast
Precautions
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Disclaimer
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