For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TTBK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9370965 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tau-Tubulin Kinase 2 (TTBK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TTBK2. The ELISA analytical biochemical technique of the MBS9370965 kit is based on TTBK2 antibody-TTBK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TTBK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TTBK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

54,037 Da

tau tubulin kinase 2

tau-tubulin kinase 2

Tau-tubulin kinase 2

KIAA0847??[Similar Products]

TTBK2_HUMAN

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: centriole; cytosol; extracellular space; nucleus

Molecular Function: protein binding; protein serine/threonine kinase activity

Biological Process: cilium biogenesis; peptidyl-serine phosphorylation; regulation of cell shape; smoothened signaling pathway

Disease: Spinocerebellar Ataxia 11

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