Product Name
Major prion protein (PRNP), Recombinant Protein
Full Product Name
Recombinant Cricetulus griseus Major prion protein (PRNP)
Product Synonym Names
Major prion protein; PrP; PrP27-30; PrP33-35C; CD_antigen=; CD230
Product Gene Name
PRNP recombinant protein
[Similar Products]
Product Synonym Gene Name
PRNP; PRP[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
23-231aa; full length protein
Sequence
KKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGTWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHNQWN KPSKPKTNMK HVAGAAAAGA VVGGLGGYML GSAMSRPMLH FGNDWEDRYY RENMNRYPNQ VYYRPVDQYN NQNNFVHDCV NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCVTQYQK ESQAYYDGRR S
3D Structure
ModBase 3D Structure for Q60506
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PRNP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PRNP. It may not necessarily be applicable to this product.
NCBI Accession #
XP_003499061.1
[Other Products]
NCBI GenBank Nucleotide #
XM_003499013.2
[Other Products]
UniProt Primary Accession #
Q60506
[Other Products]
UniProt Related Accession #
Q60506[Other Products]
Molecular Weight
27,823 Da
NCBI Official Full Name
major prion protein
NCBI Official Symbol
Prnp??[Similar Products]
NCBI Official Synonym Symbols
PRP; PrP27-30; PrP33-35C
??[Similar Products]
NCBI Protein Information
prion protein; Major prion protein
UniProt Protein Name
Major prion protein
UniProt Synonym Protein Names
PrP27-30; PrP33-35C; CD_antigen: CD230
Protein Family
Major prion protein
UniProt Gene Name
PRNP??[Similar Products]
UniProt Synonym Gene Names
PRP; PrP??[Similar Products]
UniProt Entry Name
PRIO_CRIGR
UniProt Comments for PRNP
Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
