Product Name
CACNA1, Polyclonal Antibody
Full Product Name
CACNA1 Antibody
Product Synonym Names
CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
Product Gene Name
anti-CACNA1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54289
Specificity
The antibody detects endogenous levels of total CACNA1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
2 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, L type, alpha 1D subunit
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-CACNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNA1 antibody
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-CACNA1 antibody
Total protein Ab
Applications Tested/Suitable for anti-CACNA1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-CACNA1 antibody
Immunohistochemistry: 1:25-1:100
Immunohistochemistry (IHC) of anti-CACNA1 antibody
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/30.
Immunohistochemistry (IHC) of anti-CACNA1 antibody
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/30.
NCBI/Uniprot data below describe general gene information for CACNA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713.2
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NCBI GenBank Nucleotide #
NM_000722.3
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UniProt Primary Accession #
P54289
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UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
122,443 Da
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, alpha 2/delta subunit 1
NCBI Official Symbol
CACNA2D1??[Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
??[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
UniProt Gene Name
CACNA2D1??[Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3??[Similar Products]
UniProt Entry Name
CA2D1_HUMAN
NCBI Summary for CACNA1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for CACNA1
CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: sarcoplasmic reticulum; T-tubule; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; metal ion binding
Biological Process: calcium ion transport; regulation of calcium ion transport
Research Articles on CACNA1
1. High prevalence of CACNA2D1, SCN5A, and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.
Precautions
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Disclaimer
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