Product Name
CACNA2D1, Polyclonal Antibody
Full Product Name
CACNA2D1 antibody - middle region
Product Gene Name
anti-CACNA2D1 antibody
[Similar Products]
Product Synonym Gene Name
CACNA2; CCHL2A; CACNL2A[Similar Products]
Antibody/Peptide Pairs
CACNA2D1 peptide (MBS3227345) is used for blocking the activity of CACNA2D1 antibody (MBS3202367)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI
3D Structure
ModBase 3D Structure for P54289
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CACNA2D1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CACNA2D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNA2D1 antibody
This is a rabbit polyclonal antibody against CACNA2D1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Product Categories/Family for anti-CACNA2D1 antibody
Polyclonal; Ion Channel; Signal Proteins; MAPK Signaling;
Applications Tested/Suitable for anti-CACNA2D1 antibody
Western Blot (WB)
Western Blot (WB) of anti-CACNA2D1 antibody
Host: Rabbit
Target Name: CACNA2D1
Sample Type: Fetal Muscle
Lane A: Primary Antibody
Lane B: Primary Antibody + Blocking Peptide
Primary Antibody Concentration: 1ug/ml
Peptide Concentration: 5ug/ml
Lysate Quantity: 25ug/lane/Lane
Gel Concentration: 0.12
Western Blot (WB) of anti-CACNA2D1 antibody
WB Suggested Anti-CACNA2D1 Antibody Titration: 0.12ug/ml
ELISA Titer: 1:312500
Positive Control: Human Muscle
NCBI/Uniprot data below describe general gene information for CACNA2D1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713
[Other Products]
NCBI GenBank Nucleotide #
NM_000722
[Other Products]
UniProt Primary Accession #
P54289
[Other Products]
UniProt Related Accession #
P54289[Other Products]
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1??[Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
??[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1Cleaved into the following 2 chains:Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNA2D1??[Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3??[Similar Products]
UniProt Entry Name
CA2D1_HUMAN
NCBI Summary for CACNA2D1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Research Articles on CACNA2D1
1. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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