CLTR1; CYSLT1; CYSLT1R; CYSLTR; cysteinyl leukotriene D4 receptor; cysteinyl leukotriene receptor 1; HG55; HMTMF81; LTD4 receptor

For Research Use Only. Not for use in diagnostic procedures.

CLTR1 antibody detects endogenous levels of total CLTR1 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-CLTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000

Peptide-+ Western blot analysis of extracts from COS7 cells, using CLTR1 antibody. Immunofluorescence analysis of HUVEC cells, using CLTR1 antibody.

38,541 Da

cysteinyl leukotriene receptor 1

cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1

CYSLT1; CysLTR1; LTD4 receptor??[Similar Products]

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Lynch K.R., Nature 399:789-793(1999). Sarau H.M., Mol. Pharmacol. 56:657-663(1999). Ross M.T., Nature 434:325-337(2005).

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