Full Product Name
RP2 Antibody
Product Synonym Names
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3;
Product Gene Name
anti-RP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75695
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human RP2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-RP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RP2 antibody
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
Product Categories/Family for anti-RP2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-RP2 antibody
Western Blot (WB)
Application Notes for anti-RP2 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-RP2 antibody
Western blot analysis of extracts of Jurkat cellline, using RP2antibody.
NCBI/Uniprot data below describe general gene information for RP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_008846.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006915.2
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UniProt Primary Accession #
O75695
[Other Products]
UniProt Secondary Accession #
Q86XJ7; Q9NU67[Other Products]
UniProt Related Accession #
O75695[Other Products]
NCBI Official Full Name
protein XRP2
NCBI Official Synonym Full Names
RP2, ARL3 GTPase activating protein
NCBI Official Symbol
RP2??[Similar Products]
NCBI Official Synonym Symbols
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3
??[Similar Products]
NCBI Protein Information
protein XRP2
UniProt Protein Name
Protein XRP2
UniProt Gene Name
RP2??[Similar Products]
NCBI Summary for RP2
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
UniProt Comments for RP2
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Research Articles on RP2
1. RP2 mutation would have a moderate pathogenic effect in photoreceptors carrying the mutation, causing abnormal outer segments, with the accumulation of lipofuscin similar to RDS/PRPH2 pattern dystrophy.
Precautions
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Disclaimer
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