Product Name
RP2, Blocking Peptide
Full Product Name
RP2 Peptide - middle region
Product Gene Name
RP2 blocking peptide
[Similar Products]
Product Synonym Gene Name
KIAA0215; TBCCD2; XRP2; NME10; DELXp11.3[Similar Products]
RP2 peptide (MBS3237898) is used for blocking the activity of RP2 antibody (MBS3212953)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75695
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of RP2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RP2 blocking peptide
This is a synthetic peptide designed for use in combination with anti-RP2 antibody made
Target Description: The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefo
Product Categories/Family for RP2 blocking peptide
Peptide
Applications Tested/Suitable for RP2 blocking peptide
Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for RP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_008846
[Other Products]
NCBI GenBank Nucleotide #
NM_006003
[Other Products]
UniProt Primary Accession #
O75695
[Other Products]
UniProt Related Accession #
O75695[Other Products]
NCBI Official Full Name
protein XRP2
NCBI Official Synonym Full Names
RP2 activator of ARL3 GTPase
NCBI Official Symbol
RP2??[Similar Products]
NCBI Official Synonym Symbols
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3
??[Similar Products]
NCBI Protein Information
protein XRP2
UniProt Protein Name
Protein XRP2
UniProt Gene Name
RP2??[Similar Products]
UniProt Entry Name
XRP2_HUMAN
NCBI Summary for RP2
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
UniProt Comments for RP2
RP2: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2); also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the TBCC family.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: centriole; Golgi apparatus; cytoplasm; plasma membrane; cytoplasmic vesicle
Molecular Function: protein binding; GTP binding; unfolded protein binding; nucleoside diphosphate kinase activity; actin binding; GTPase activator activity; ATP binding
Biological Process: GTP biosynthetic process; CTP biosynthetic process; protein transport; protein folding; visual perception; organelle organization and biogenesis; UTP biosynthetic process; cell morphogenesis; nucleoside diphosphate phosphorylation; cytoskeleton organization and biogenesis; post-Golgi vesicle-mediated transport; post-chaperonin tubulin folding pathway; positive regulation of GTPase activity
Disease: Retinitis Pigmentosa 2
Research Articles on RP2
1. T, c.2002dupC and c.2236_2237del CT, as well as a previously reported mutation of c.2899delG were detected in the RPGR gene in the other four families. Our study further expands the mutation spectrum of RP2 and RPGR, and will be helpful for further study molecular pathogenesis of X-linked retinitis pigmentosa.">four frameshift mutations including three novel mutations of c.1059 + 1 G > T, c.2002dupC and c.2236_2237del CT, as well as a previously reported mutation of c.2899delG were detected in the RPGR gene in the other four families. Our study further expands the mutation spectrum of RP2 and RPGR, and will be helpful for further study molecular pathogenesis of X-linked retinitis pigmentosa.
Precautions
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Disclaimer
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