Product Name
CACNA2D1, Polyclonal Antibody
Full Product Name
Goat anti-CACNA2D1 Antibody
Product Synonym Names
CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1; CACNA2; CACNL2A; CCHL2A; MHS3; H_DJ0560O14.1; WUGSC: H_DJ0560O14.1; calcium channel, L type, alpha 2 polypeptide; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; CACNA2D1 antibody; calcium channel; voltage-dependent; alpha 2/delta subunit 1 antibody; CACNA2 antibody; CACNL2A antibody; CCHL2A antibody; MHS3 antibody; H_DJ0560O14.1 antibody; WUGSC: H_DJ0560O14.1 antibody; calcium channel; L type; alpha 2 polypeptide antibody; dihydropyridine-sensitive L-type; calcium channel alpha-2/delta subunit antibody
Product Gene Name
anti-CACNA2D1 antibody
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Antibody/Peptide Pairs
CACNA2D1 peptide (MBS426764) is used for blocking the activity of CACNA2D1 antibody (MBS420998)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QEIFNKYNKD KKVR
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QEIFNKYNKDKKVR, from the internal region of the protein sequence according to NP_000713.2.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CACNA2D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CACNA2D1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-CACNA2D1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 140kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 123kDa according to NP_000713.2). Recommended concentration: 0. 03-0.1ug/ml. Customer found it not suitable on Mouse and Rat protein.
Western Blot (WB) of anti-CACNA2D1 antibody
(0. 03ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
NCBI/Uniprot data below describe general gene information for CACNA2D1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000722.3
[Other Products]
UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
122,443 Da
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1??[Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
??[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNA2D1??[Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3??[Similar Products]
UniProt Entry Name
CA2D1_HUMAN
NCBI Summary for CACNA2D1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for CACNA2D1
CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: plasma membrane; sarcoplasmic reticulum; voltage-gated calcium channel complex
Molecular Function: metal ion binding; voltage-gated calcium channel activity
Biological Process: calcium ion transport; regulation of calcium ion transport
Research Articles on CACNA2D1
1. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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