Product Name
CACNA2D1, Polyclonal Antibody
Full Product Name
CACNA2D1 Polyclonal Antibody
Product Synonym Names
CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3
Product Gene Name
anti-CACNA2D1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DIKVEIRNKM IDGESGEKTF RTLVKSQDER YIDKGNRTYT WTPVNGTDYS LALVLPTYSF YYIKAKLEET ITQARSKKGK MKDSETLKPD NFEESGYTFI APRDYCNDLK ISDNNTEFLL NFNEFIDRKT PNNPSCNADL INRVLLDAGF TNELVQNYWS KQKNIKGVKA RFVVTDGGIT RVYPKEAGEN WQENPETYED SFYKRSLDND NYVFTAPYFN KSGPGAYESG IMVSKAVEIY IQGKLLKPAV V
3D Structure
ModBase 3D Structure for P54289
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human CACNA2D1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Membrane, Single-pass type I membrane protein
Positive Samples
LO2, 293T, Mouse brain, Mouse heart, Mouse kidney
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-CACNA2D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNA2D1 antibody
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
Product Categories/Family for anti-CACNA2D1 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-CACNA2D1 antibody
Western Blot (WB)
Application Notes for anti-CACNA2D1 antibody
WB: 1:200 - 1:2000
Western Blot (WB) of anti-CACNA2D1 antibody
Western blot analysis of extracts of various cell lines, using CACNA2D1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5S.
NCBI/Uniprot data below describe general gene information for CACNA2D1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713.2
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NCBI GenBank Nucleotide #
NM_000722.3
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UniProt Primary Accession #
P54289
[Other Products]
UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
Calculated: 121kDa; 122kDa; 123kDa; 124kDa
Observed: 124kDa
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1??[Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
??[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNA2D1??[Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3??[Similar Products]
NCBI Summary for CACNA2D1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for CACNA2D1
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling ().
Research Articles on CACNA2D1
1. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction
Precautions
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Disclaimer
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