CYSLT1 antibody; CYSLT1R antibody; CYSLTR antibody; HG55 antibody; HMTMF81 antibody; MGC46139 antibody; CYSLTR1 antibody; cysteinyl leukotriene receptor 1 antibody; cysteinyl leukotriene D4 receptor antibody; LTD4 receptor antibody; G-protein coupled rece

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total CysLT1 Receptor protein.

Antibodies were purified by antigen-affinity chromatography.

Rabbit IgG in 1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

0.38 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-CysLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq]

Total protein Ab

Western Blot (WB)

Western blotting: 1:500-1:3000

Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE diluted at 1:1000

38,541 Da

cysteinyl leukotriene receptor 1

cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1

CYSLT1; CysLTR1; LTD4 receptor??[Similar Products]

CLTR1_HUMAN

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13.2-q21.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; inflammatory response; chemotaxis

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