Full Product Name
TTBK2 Polyclonal Antibody
Product Synonym Names
TTBK; SCA11
Product Gene Name
anti-TTBK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purification
Concentration
3mg/ml (lot specific)
Immunogen
Synthetic peptide of human TTBK2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165430
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-TTBK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TTBK2 antibody
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Applications Tested/Suitable for anti-TTBK2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-TTBK2 antibody
ELISA: 1:2000-10000
IHC: 1:30-150
Immunohistochemistry (IHC) of anti-TTBK2 antibody
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TTBK2 Polyclonal Antibody at dilution 1:45
Immunohistochemistry (IHC) of anti-TTBK2 antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TTBK2 Polyclonal Antibody at dilution 1:45
NCBI/Uniprot data below describe general gene information for TTBK2. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_173500.3
[Other Products]
UniProt Secondary Accession #
O94932; Q6ZN52; Q8IVV1[Other Products]
UniProt Related Accession #
Q6IQ55[Other Products]
Molecular Weight
54,037 Da
NCBI Official Full Name
tau-tubulin kinase 2
NCBI Official Synonym Full Names
tau tubulin kinase 2
NCBI Official Symbol
TTBK2??[Similar Products]
NCBI Official Synonym Symbols
TTBK; SCA11
??[Similar Products]
NCBI Protein Information
tau-tubulin kinase 2
UniProt Protein Name
Tau-tubulin kinase 2
Protein Family
Tau-tubulin kinase
UniProt Gene Name
TTBK2??[Similar Products]
UniProt Synonym Gene Names
KIAA0847??[Similar Products]
UniProt Entry Name
TTBK2_HUMAN
NCBI Summary for TTBK2
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
UniProt Comments for TTBK2
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Research Articles on TTBK2
1. TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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