Product Name
TTBK2, cDNA Clone
Full Product Name
TTBK2 cDNA Clone
Product Gene Name
TTBK2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagtgggg gaggagagca gccggatatc ctgagtgttg gaatcctagt gaaagaaaga tggaaagtgt tgagaaagat tgggggtggg ggctttggag aaatttacga tgccttggac atgctcacca gggaaaatgt tgcactgaag gtggaatcag ctcaacaacc aaaacaagtt ctgaaaatgg aagttgctgt tttgaaaaag ctgcaaggga aagaccatgt ttgtagattt attggctgtg ggaggaatga tcgattcaac tatgtggtca tgcagttgca gggtcggaat ctggcagatc ttcgccgtag ccagtcccga ggcacattca ccattagtac cactctccgg ctgggtagac agattttgga gtctattgaa agcattcatt ctgtgggatt cttgcatcga gacatcaaac cgtcgaactt cgctatgggt cgctttccta gtacatgtag gaaatgttac atgcttgatt ttggcttggc tcgacaattt accaattcct gtggtgacgt cagaccacct cgagctgtgg caggttttcg agggacagtt cgttatgcat caatcaacgc acatcggaac agggaaatgg gaagacatga tgacctttgg tccttattct acatgttggt ggagtttgtg gttggtcagc tgccctggag aaaaataaag gacaaggagc aagtaggctc tattaaggag agatatgacc acaggctcat gttgaaacat ctccctccag aattcagcat ctttctagac catatctctt ctttggatta ttttacaaaa ccagactacc agcttcttac atccgtgttt gacaatagca tcaagacttt tggagtaatt gagagtgacc cttttgactg ggagaagact ggaaatgatg gctccctaac aaccaccact acttctacca cccctcagtt gcacactcgc ttgacccctg ctgcaattgg aattgccaat gctactccca tccctggaga cttgcttcga gaaaatacag atgaggtatt tccagatgaa cagcttagcg atggagaaaa tggcatccct gttggtgtgt caccagataa attgcctgga tctctgggac acccccgtcc ccaggagaag gatgtttggg aagagatgga tgccaacaaa aacaagataa agcttggaat ttgtaaggct gctactgaag aggagaacag ccatggccag gcaaatggtc ttctcaatgc tccaagcctt gggtcaccaa ttcgtgtccg ctcagagatt actcagccag acagagatat tccactggtg cgaaagttac gttccattca cagctttgag ctggaaaaac gtctgaccct ggagccaaag ccagacactg acaagttcct tgagacctgc ctggagaaaa tgcagaaaga taccagtgca ggaaaagaat ctattctccc tgctctgctg cataagcctt gcgttcctgc tgtgtcccgt actgaccaca tctggcacta tgatgaagaa tatcttccag atgcctccaa gcctgcttct gccaacaccc ctgagcaggc agatggtggt ggcagcaatg gatttatagc tgttaacctg agctcttgca agcaagaaat tgattccaaa gaatgggtga ttgtggacaa ggagcaggac cttcaggatt ttaggacaaa tgaggctgta ggacataaaa caactggaag tccttctgat gaggagcctg aagtacttca agtcctggag gcatcacctc aagatgaaaa gctccagtta ggtccttggg cagaaaatga tcatttaaag aaggaaacct caggtgtggt cttagcactt tctgcagagg gtcctcctac tgctgcttca gaacaatata cagataggct ggaactccag cctggagctg ctagtcagtt tattgcagcg acgcccacaa gtctaatgga ggcgcaggca gaaggacccc ttacagcgat tacaattcct agaccttctg tggcatctac acagtcaact tcaggaagct ttcactgtgg tcagcagcca gagaagaaag atcttcagcc catggagccc actgtggaac tttactctcc aagggaaaac ttctctggct tggttgtgac agagggtgaa cctcctagtg gaggaagcag aacagatttg gggcttcaga tagatcacat tggtcatgac atgttaccca acattagaga aagtaacaaa tctcaagacc tgggaccaaa agaacttcct gatcataata gactggttgt gagagaattt gaaaatctcc ctggggaaac tgaagagaaa agcatccttt tagagtcaga taatgaagat gagaagttaa gtagagggca gcattgtatt gagatctcct ctctcccagg agatttggta attgtggaaa aggatcactc agctactact gaacctcttg atgtgacaaa aacacagact tttagtgtgg tgccaaatca agacaaaaat aatgagataa tgaagcttct gacagttgga acttcagaaa tttcttccag agacattgac ccacatgttg aaggtcagat aggccaagtg gcagaaatgc aaaaaaataa gatatctaag gatgatgaca tcatgagtga agacttgcca ggtcatcaag gagacctctc tacttttttg caccaagagg gcaagagaga gaaaatcacc cctagaaatg gagaactatt tcattgtgtt tcagagaatg aacatggtgc cccaacccgg aaggatatgg ttaggtcatc ctttgtaact agacacagcc gaatccctgt tttagcacaa gagatagact caactttgga atcatcctct ccagtttctg caaaagaaaa gctcctccaa aagaaagcct atcagccaga cctagtcaag cttctggtgg aaaaaagaca attcaagtcc ttccttggcg acctctcaag tgcctctgat aaattgctag aggagaaact agctactgtt cctgctccct tttgtgagga ggaagtgctc actccctttt caagactgac agtagattct cacctgagta ggtcagctga agatagcttt ctgtcaccca tcatctccca gtctagaaag agcaaaattc caaggccagt ttcatgggtc aacacagatc aggtcaatag ctcaacttcg tctcagttct ttcctcggcc accaccagga aagccaccca cgaggcctgg agtagaagcc aggctacgca gatataaagt cctagggagt agtaactccg actcagacct tttctcccgc ctggcccaaa ttcttcaaaa tggatctcag aaaccccgga gcactactca gtgcaagagt ccaggatctc ctcacaatcc aaaaacacca cccaagagtc cagttgtccc tcgcaggagt cccagtgcct ctcctcgaag ctcatccttg cctcgcacgt ctagttcctc accatctagg gctggacggc cccaccatga ccagaggagt tcgtccccac atctggggag aagcaagtca cctcccagcc actcaggatc ttcctcctcc aggaggtcct gccaacagga gcattgcaaa cccagcaaga atggcctgaa aggatccggc agcctccacc accactcagc cagcactaaa accccccaag ggaagagtaa gccagccagt aaactcagca gatag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TTBK2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TTBK2. It may not necessarily be applicable to this product.
NCBI Accession #
BC071556
[Other Products]
UniProt Secondary Accession #
O94932; Q6ZN52; Q8IVV1[Other Products]
UniProt Related Accession #
Q6IQ55[Other Products]
Molecular Weight
54,037 Da
NCBI Official Full Name
Homo sapiens tau tubulin kinase 2, mRNA
NCBI Official Synonym Full Names
tau tubulin kinase 2
NCBI Official Symbol
TTBK2??[Similar Products]
NCBI Official Synonym Symbols
TTBK; SCA11
??[Similar Products]
NCBI Protein Information
tau-tubulin kinase 2
UniProt Protein Name
Tau-tubulin kinase 2
Protein Family
Tau-tubulin kinase
UniProt Gene Name
TTBK2??[Similar Products]
UniProt Synonym Gene Names
KIAA0847??[Similar Products]
UniProt Entry Name
TTBK2_HUMAN
NCBI Summary for TTBK2
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
UniProt Comments for TTBK2
TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); CK1 group; TTBK family
Chromosomal Location of Human Ortholog: 15q15.2
Cellular Component: centriole; cytosol; extracellular space; nucleus
Molecular Function: protein binding; protein serine/threonine kinase activity
Biological Process: cilium biogenesis; peptidyl-serine phosphorylation; regulation of cell shape; smoothened signaling pathway
Disease: Spinocerebellar Ataxia 11
Research Articles on TTBK2
1. TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.
Precautions
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Disclaimer
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