Full Product Name
Cacna2d1 Antibody
Product Gene Name
anti-Cacna2d1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54289
Other Notes
Small volumes of anti-Cacna2d1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-Cacna2d1 antibody
Western blot analysis Cacna2d1 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for Cacna2d1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713.2
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NCBI GenBank Nucleotide #
NM_000722.3
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UniProt Primary Accession #
P54289
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UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
122,443 Da
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1??[Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
??[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNA2D1??[Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3??[Similar Products]
NCBI Summary for Cacna2d1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for Cacna2d1
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling ().
Research Articles on Cacna2d1
1. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction
Precautions
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Disclaimer
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