Human Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) ELISA kit; H_DJ0560O14.1; CACNA2; CACNL2A; CCHL2A; calcium channel; L type; alpha 2 polypeptide; dihydropyridine-sensitive L-type; calcium channel alpha-2/delta subunit; calcium channel; voltage-dependent; alpha 2/delta subunit 1

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

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Small volumes of CACNA2D1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330037 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the calcium channel, voltage-dependent, alpha 2/delta subunit 1 (CACNA2D1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNA2D1. The ELISA analytical biochemical technique of the MBS9330037 kit is based on CACNA2D1 antibody-CACNA2D1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNA2D1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNA2D1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CACNA2D1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

124,568 Da

calcium channel, voltage-dependent, alpha 2/delta subunit 1

voltage-dependent calcium channel subunit alpha-2/delta-1; long intergenic non-protein coding RNA 1112; calcium channel, L type, alpha 2 polypeptide; voltage-gated calcium channel subunit alpha-2/delta-1; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit

Voltage-dependent calcium channel subunit alpha-2/delta-1

CACNL2A; CCHL2A; MHS3??[Similar Products]

CA2D1_HUMAN

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: sarcoplasmic reticulum; T-tubule; voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; metal ion binding

Biological Process: calcium ion transport; regulation of calcium ion transport

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