Product Name
GDNF family receptor alpha-1 (Gfra1), Recombinant Protein
Full Product Name
Recombinant Mouse GDNF family receptor alpha-1 (Gfra1)
Product Gene Name
Gfra1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
25-430aa, Full Length of Mature Protein
Sequence
DRLDCVKASD QCLKEQSCST KYRTLRQCVA GKETNFSLTS GLEAKDECRS AMEALKQKSL YNCRCKRGMK KEKNCLRIYW SMYQSLQGND LLEDSPYEPV NSRLSDIFRA VPFISDVFQQ VEHISKGNNC LDAAKACNLD DTCKKYRSAY ITPCTTSMSN EVCNRRKCHK ALRQFFDKVP AKHSYGMLFC SCRDVACTER RRQTIVPVCS YEERERPNCL NLQDSCKTNY ICRSRLADFF TNCQPESRSV SNCLKENYAD CLLAYSGLIG TVMTPNYIDS SSLSVAPWCD CSNSGNDLED CLKFLNFFKD NTCLKNAIQA FGNGSDVTMW QPAPPVQTTT ATTTTAFRIK NKPLGPAGSE NEIPTHVLPP CANLQAQKLK SNVSGSTHLC LSDNDYGKDG LAGASS
3D Structure
ModBase 3D Structure for P97785
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Gfra1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Gfra1 recombinant protein
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This protein is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
NCBI/Uniprot data below describe general gene information for Gfra1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001272386.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001285457.2
[Other Products]
UniProt Primary Accession #
P97785
[Other Products]
UniProt Secondary Accession #
O35246; O35252[Other Products]
UniProt Related Accession #
P97785[Other Products]
Molecular Weight
51,134 Da
NCBI Official Full Name
GDNF family receptor alpha-1 isoform 2
NCBI Official Synonym Full Names
glial cell line derived neurotrophic factor family receptor alpha 1
NCBI Official Symbol
Gfra1??[Similar Products]
NCBI Official Synonym Symbols
AU042498
??[Similar Products]
NCBI Protein Information
GDNF family receptor alpha-1
UniProt Protein Name
GDNF family receptor alpha-1
UniProt Synonym Protein Names
TGF-beta-related neurotrophic factor receptor 1
Protein Family
GDNF family receptor
UniProt Gene Name
Gfra1??[Similar Products]
UniProt Synonym Gene Names
Gdnfra; Trnr1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1??[Similar Products]
NCBI Summary for Gfra1
This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]
UniProt Comments for Gfra1
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor ().
Research Articles on Gfra1
1. GFRA1 regulates AMPK-dependent autophagy by promoting SRC phosphorylation independent of proto-oncogene RET kinase
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
