Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81; CYSLTR1; CYSLT1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CYSLTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the Central region of human CYSLTR1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CYSLTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are
important mediators of human bronchial asthma. Pharmacologic
studies have determined that cysteinyl leukotrienes activate at
least 2 receptors, the protein encoded by this gene and CYSLTR2.
This encoded receptor is a member of the superfamily of G
protein-coupled receptors. Activation of this receptor by LTD4
results in contraction and proliferation of smooth muscle, oedema,
eosinophil migration and damage to the mucus layer in the lung.

Neuroscience; GPCR Antibodies

WB, IHC-P , E.

WB~~1:1000
IHC-P~~1:10~50

CYSLTR1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYSLTR1 antibody detected the CYSLTR1 protein (arrow).

CYSLTR1 Antibody (Center) (MBS9207739)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYSLTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

cysteinyl leukotriene receptor 1

cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1

CYSLT1; CysLTR1; LTD4 receptor??[Similar Products]

CLTR1_HUMAN

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq13.2-q21.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; inflammatory response; chemotaxis

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Sokolowska, M., et al. BMC Immunol. 10, 63 (2009) :

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