Pro-opiomelanocortin; proopiomelanocortin; ACTH antibody; Adrenocorticotropic hormone antibody; Adrenocorticotropin antibody; Adrenocorticotropin Hormone antibody; Alpha Melanocyte Stimulating Hormone antibody; alpha-MSH antibody; alphaMSH antibody; Beta Endorphin antibody; Beta Lipotropin antibody; Beta LPH antibody; Beta Melanocyte Stimulating Hormone antibody; Beta-endorphin antibody; beta-MSH antibody; CLIP antibody; Corticotropin antibody; Corticotropin Like Intermediary Peptide antibody; Corticotropin lipotropin antibody; Corticotropin lipotropin precursor antibody; Corticotropin-like intermediary peptide antibody; Gamma LPH antibody; gamma-MSH antibody; Lipotropin Beta antibody; Lipotropin Gamma antibody; Lipotropin, included antibody; LPH antibody; Melanocyte-stimulating hormone, included antibody; Melanotropin Alpha antibody; Melanotropin beta antibody; Melanotropin gamma antibody; Melanotropin, included antibody; Met Enkephalin antibody; Met-enkephalin antibody; MSH antibody; NPP antibody; Opiomelanocortin prepropeptide antibody; POC antibody; POMC antibody; Pomc-1 antibody; Pomc1 antibody; Pomc2 antibody; Pro ACTH endorphin antibody; Pro opiomelanocortin antibody; Pro-opiomelanocortin-alpha antibody; Proopiomelanocortin antibody; Proopiomelanocortin preproprotein antibody; Tetracosactide antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-POMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Rabbit IgG polyclonal antibody for Pro-opiomelanocortin(POMC) detection. Tested with IHC-P in Human, Mouse, Rat.
Background: Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

Immunohistochemistry (IHC) Paraffin

Anti-ACTH Picoband antibody, MBS176775-1.JPG
IHC(P): Mouse Kidney Tissue

Anti-ACTH Picoband antibody, MBS176775-2.JPG
IHC(P): Rat Brain Tissue

Anti-ACTH Picoband antibody, MBS176775-3.JPG
IHC(P): Rat Kidney Tissue

29,424 Da

proopiomelanocortin

pro-opiomelanocortin; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; adrenocorticotropin; corticotropin-lipotropin; adrenocorticotropic hormone; opiomelanocortin prepropeptide; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide

Pro-opiomelanocortin

POMC; ACTH; CLIP??[Similar Products]

COLI_HUMAN

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: extracellular space; peroxisomal matrix; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; type 4 melanocortin receptor binding; hormone activity; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; glucose homeostasis; signal transduction; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency

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