Full Product Name
Goat Polyclonal to Human CHD7
Product Synonym Names
Anti-CHD7 Antibody (Internal) IHC-plus; CHD7; ATP-dependent helicase CHD7; HH5; KAL5; CHD-7; IS3; KIAA1416; Human CHD7
Product Gene Name
anti-CHD7 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9P2D1
Species Reactivity
Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity)
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Immunogen Description
Synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%).
Immunogen Type
Synthetic peptide
Immunogen
CHD7 antibody was raised against synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%), Elephant (92%), Panda (92%), Bovine (92%), Dog (92%), Bat (92%), Horse (92%), Pig (92%), Opossum (92%), Turkey (92%), Chicken (92%), Lizard (92%), Rabbit (85%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHD7 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-CHD7 antibody
ELISA (1:64000), IHC-P (3.75 ug/ml)
Immunohistochemistry (IHC) of anti-CHD7 antibody
Anti-CHD7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060250.2
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NCBI GenBank Nucleotide #
NM_017780.3
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UniProt Primary Accession #
Q9P2D1
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UniProt Secondary Accession #
Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2[Other Products]
UniProt Related Accession #
Q9P2D1[Other Products]
Molecular Weight
101,085 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Symbol
CHD7??[Similar Products]
NCBI Official Synonym Symbols
CRG; HH5; IS3; KAL5
??[Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7; CHARGE association; ATP-dependent helicase CHD7; chromodomain helicase DNA binding protein 7 isoform CRA_e
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD7??[Similar Products]
UniProt Synonym Gene Names
KIAA1416; CHD-7??[Similar Products]
UniProt Entry Name
CHD7_HUMAN
NCBI Summary for CHD7
This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for CHD7
CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and ***** tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Helicase; DNA-binding; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 8q12.2
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding
Biological Process: heart morphogenesis; limb development; central nervous system development; olfactory behavior; blood circulation; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; ***** walking behavior; female genitalia development; embryonic hindlimb morphogenesis; olfactory nerve development; sensory perception of sound; regulation of neurogenesis; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; ***** heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing
Disease: Charge Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Research Articles on CHD7
1. CHD7 was dysregulated, ranking above the 90th percentile in differential expression in a panel of PDAC clinical specimens, highlighting its potential as a biomarker.
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