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CHD7, Polyclonal Antibody

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CHD7, Polyclonal Antibody


CHD7, Polyclonal Antibody  的詳細(xì)介紹
Product Name

CHD7, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human CHD7

Product Synonym Names
Anti-CHD7 Antibody (Internal) IHC-plus; CHD7; ATP-dependent helicase CHD7; HH5; KAL5; CHD-7; IS3; KIAA1416; Human CHD7
Product Gene Name

anti-CHD7 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
gene 612370
3D Structure
ModBase 3D Structure for Q9P2D1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity)
Specificity
Human CHD7.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%).
Immunogen Type
Synthetic peptide
Immunogen
CHD7 antibody was raised against synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%), Elephant (92%), Panda (92%), Bovine (92%), Dog (92%), Bat (92%), Horse (92%), Pig (92%), Opossum (92%), Turkey (92%), Chicken (92%), Lizard (92%), Rabbit (85%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-CHD7 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-CHD7 antibody
ELISA (1:64000), IHC-P (3.75 ug/ml)

Immunohistochemistry (IHC) of anti-CHD7 antibody
Anti-CHD7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-CHD7 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.
NCBI GI #
54112403
NCBI GeneID
55636
NCBI Accession #
NP_060250.2 [Other Products]
NCBI GenBank Nucleotide #
NM_017780.3 [Other Products]
UniProt Primary Accession #
Q9P2D1 [Other Products]
UniProt Secondary Accession #
Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2[Other Products]
UniProt Related Accession #
Q9P2D1[Other Products]
Molecular Weight
101,085 Da
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NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Symbol
CHD7??[Similar Products]
NCBI Official Synonym Symbols
CRG; HH5; IS3; KAL5
??[Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7; CHARGE association; ATP-dependent helicase CHD7; chromodomain helicase DNA binding protein 7 isoform CRA_e
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD7??[Similar Products]
UniProt Synonym Gene Names
KIAA1416; CHD-7??[Similar Products]
UniProt Entry Name
CHD7_HUMAN
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NCBI Summary for CHD7
This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. [provided by RefSeq, Jul 2008]
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UniProt Comments for CHD7
CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and ***** tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Helicase; DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 8q12.2

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding

Biological Process: heart morphogenesis; limb development; central nervous system development; olfactory behavior; blood circulation; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; ***** walking behavior; female genitalia development; embryonic hindlimb morphogenesis; olfactory nerve development; sensory perception of sound; regulation of neurogenesis; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; ***** heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing

Disease: Charge Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Research Articles on CHD7
1. CHD7 was dysregulated, ranking above the 90th percentile in differential expression in a panel of PDAC clinical specimens, highlighting its potential as a biomarker.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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