Immunoglobulin-binding protein 1; B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16; IGBP1; IBP1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This IGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-171 amino acids from the Central region of human IGBP1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-IGBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The proliferation and differentiation of B cells is
dependent upon a B-cell antigen receptor (BCR) complex. Binding of
antigens to specific B-cell receptors results in a tyrosine
phosphorylation reaction through the BCR complex and leads to
multiple signal transduction pathways.

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

IGBP1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IGBP1 antibody detected the IGBP1 protein (arrow).

39222

immunoglobulin (CD79A) binding protein 1

immunoglobulin-binding protein 1

Immunoglobulin-binding protein 1

IBP1; Protein alpha-4??[Similar Products]

IGBP1_HUMAN

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

IGBP1: Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family.

Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: Xq13.1-q13.3

Cellular Component: microtubule; cytoplasm

Molecular Function: protein domain specific binding; protein binding; mitogen-activated protein kinase kinase binding; protein phosphatase type 2A regulator activity

Biological Process: negative regulation of protein amino acid dephosphorylation; B cell activation; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; negative regulation of stress-activated MAPK cascade; signal transduction

Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia

McDonald, W.J., et al. J. Cell. Biochem. 110(5):1123-1129(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Fielhaber, J.A., et al. J. Biol. Chem. 284(36):24341-24353(2009)
Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)
Aranda-Orgilles, B., et al. PLoS ONE 3 (10), E3507 (2008) :

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