Product Name
IGBP1, Polyclonal Antibody
Popular Item
Full Product Name
IGBP1 Polyclonal Antibody
Product Synonym Names
ALPHA-4; IBP1
Product Gene Name
anti-IGBP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P78318
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human IGBP1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-IGBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGBP1 antibody
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
Product Categories/Family for anti-IGBP1 antibody
Primary antibody
Applications Tested/Suitable for anti-IGBP1 antibody
Western Blot (WB)
Application Notes for anti-IGBP1 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-IGBP1 antibody
Western blot analysis of extracts of various cell lines, using IGBP1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 40s.
NCBI/Uniprot data below describe general gene information for IGBP1. It may not necessarily be applicable to this product.
NCBI Accession #
P78318.1
[Other Products]
UniProt Primary Accession #
P78318
[Other Products]
UniProt Secondary Accession #
Q8TAB2[Other Products]
UniProt Related Accession #
P78318[Other Products]
NCBI Official Full Name
Immunoglobulin-binding protein 1
NCBI Official Synonym Full Names
immunoglobulin binding protein 1
NCBI Official Symbol
IGBP1??[Similar Products]
NCBI Official Synonym Symbols
IBP1; ALPHA-4
??[Similar Products]
NCBI Protein Information
immunoglobulin-binding protein 1
UniProt Protein Name
Immunoglobulin-binding protein 1
UniProt Synonym Protein Names
B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16
Protein Family
Immunoglobulin-binding protein
UniProt Gene Name
IGBP1??[Similar Products]
UniProt Synonym Gene Names
IBP1; Protein alpha-4??[Similar Products]
NCBI Summary for IGBP1
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Comments for IGBP1
IGBP1: Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family.
Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq13.1
Molecular Function: protein binding; protein phosphatase regulator activity
Biological Process: negative regulation of caspase activity; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter
Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
Research Articles on IGBP1
1. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac.
Precautions
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Disclaimer
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