Full Product Name
ALG3 Antibody
Product Synonym Names
CDGS4; D16Ertd36e; NOT56L; Not56
Product Gene Name
anti-ALG3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of ALG3
Calculated Molecular Weight: 438aa; 50kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ALG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALG3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ALG3. It may not necessarily be applicable to this product.
NCBI Accession #
AAH04313.1
[Other Products]
UniProt Secondary Accession #
Q9BT71; A8JZZ6[Other Products]
UniProt Related Accession #
Q92685[Other Products]
Molecular Weight
44,370 Da
NCBI Official Full Name
ALG3 protein, partial
NCBI Official Synonym Full Names
ALG3, alpha-1,3- mannosyltransferase
NCBI Official Symbol
ALG3??[Similar Products]
NCBI Official Synonym Symbols
CDG1D; CDGS4; Not56; NOT56L; D16Ertd36e
??[Similar Products]
NCBI Protein Information
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Not56-like protein; asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog; asparagine-linked glycosylation protein 3 homolog; carbohydrate deficient glycoprotein syndrome type IV; dol-P-Man dependent alpha(1-3)-mannosyltransferase; dol-P-Man dependent alpha-1,3- mannosyltransferase; dol-P-Man-dependent alpha(1-3)-mannosyltransferase; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
UniProt Protein Name
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 3 homolog; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; Not56-like protein
Protein Family
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Gene Name
ALG3??[Similar Products]
UniProt Synonym Gene Names
NOT; NOT56L??[Similar Products]
UniProt Entry Name
ALG3_HUMAN
NCBI Summary for ALG3
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for ALG3
ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 2.4.1.258; Endoplasmic reticulum; Transferase; Membrane protein, multi-pass; Glycan Metabolism - N-glycan biosynthesis
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: alpha-1,3-mannosyltransferase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Congenital Disorder Of Glycosylation, Type Id
Research Articles on ALG3
1. ALG3-CDG is due to an autosomal recessive defect in the ER mannosyl-transferase VI, which is involved in protein N-glycosylation. The enzyme is encoded by the ALG3 gene
Precautions
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Disclaimer
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