Product Name
ALG3, cDNA Clone
Full Product Name
ALG3 cDNA Clone
Product Gene Name
ALG3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggctg ggctgcggaa acgcggccgg tccggttccg cggcccaggc agagggactc tgcaagcaat ggctgcagcg cgcctggcaa gagcggcgcc tgctgctgcg ggagccgcgc tacacgctgc tggtggccgc ctgcctctgc ctggcggagg tgggcatcac cttctgggtc attcacaggg tggcatacac agagattgac tggaaggcct acatggccga ggtagaaggc gtcatcaatg gtacctatga ctatacccaa ctgcagggtg acaccggacc acttgtgtac ccagctggtt tcgtgtacat ctttatgggg ttgtactatg ccaccagccg aggcactgac atccgcatgg cccagaacat ctttgctgtg ctctacctgg ctaccttgct gcttgtcttc ttgatctatc accagacctg caaggtacct cccttcgtct ttttcttcat gtgctgcgcc tcttaccgtg tccactccat ctttgtgctg cggctcttca atgacccagt ggccatggtg ctgctcttcc tcagtatcaa cctcctgctg gcccagcgct ggggctgggg ttgctgcttt ttcagcctgg cagtctctgt gaagatgaat gtgctgctct tcgcccctgg gttactgttt cttctcctca cacagtttgg cttccgtggg gccctcccca agctgggaat ctgtgctggc cttcaggtgg tgctggggct gcccttcctg ctggagaacc ccagcggcta cctgtcccgc tcctttgacc ttggccgcca gtttctgttc cactggacag tgaactggcg cttcctccca gaggcgctct tcctgcatcg agccttccac ctggccctgt tgactgccca cctcaccctg ctcctgctgt ttgccctctg caggtggcac aggacagggg aaagtatctt gtcgctgctg agggatccct ccaaaaggaa ggttccaccc cagcccctta cacccaacca gatcgtttct accctcttca cctccaactt cattggcatc tgcttcagcc gctccctcca ctaccagttc tacgtctggt atttccacac actgccctac ctcctgtggg ccatgcctgc acgctggctc acacacctgc tcaggttgtt ggtgctgggg ctcatcgagc tctcctggaa cacataccct tccacatcct gcagctctgc tgccctgcac atatgccatg ccgtcatcct gctgcagctc tggctgggcc cgcagccttt ccccaagagc acccaacaca gcaagaaagc ccactga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALG3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALG3. It may not necessarily be applicable to this product.
NCBI Accession #
BC002839
[Other Products]
UniProt Secondary Accession #
Q9BT71; A8JZZ6[Other Products]
UniProt Related Accession #
Q92685[Other Products]
Molecular Weight
44,370 Da
NCBI Official Full Name
Homo sapiens asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
ALG3, alpha-1,3- mannosyltransferase
NCBI Official Symbol
ALG3??[Similar Products]
NCBI Official Synonym Symbols
not; CDG1D; CDGS4; CDGS6; Not56; NOT56L; D16Ertd36e
??[Similar Products]
NCBI Protein Information
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Protein Name
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 3 homolog; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; Not56-like protein
Protein Family
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
UniProt Gene Name
ALG3??[Similar Products]
UniProt Synonym Gene Names
NOT; NOT56L??[Similar Products]
UniProt Entry Name
ALG3_HUMAN
NCBI Summary for ALG3
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for ALG3
ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Transferase; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; EC 2.4.1.258
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: alpha-1,3-mannosyltransferase activity
Biological Process: dolichol-linked oligosaccharide biosynthetic process
Disease: Congenital Disorder Of Glycosylation, Type Id
Research Articles on ALG3
1. ALG3-CDG is due to an autosomal recessive defect in the ER mannosyl-transferase VI, which is involved in protein N-glycosylation. The enzyme is encoded by the ALG3 gene
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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