Full Product Name
CHD7 Antibody
Product Synonym Names
Chromodomain helicase DNA binding protein 7, IS3, KAL5
Product Gene Name
anti-CHD7 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9P2D1
Species Reactivity
Human, Mouse
Specificity
Multiple isoforms of CHD7 are known to exist.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Description
Raised against an 18 amino acid peptide near the amino terminus of human CHD7.
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHD7 antibody
CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.
Product Categories/Family for anti-CHD7 antibody
Total protein Ab
Applications Tested/Suitable for anti-CHD7 antibody
ELISA (EIA), Western Blot (WB)
Western Blot (WB) of anti-CHD7 antibody
Western blot analysis of CHD7 in SK-N-SH cell lysate with CHD7 antibody at (A) 1 and (B) 2 ug/mL.
NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060250.2
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NCBI GenBank Nucleotide #
NM_017780.3
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UniProt Primary Accession #
Q9P2D1
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UniProt Secondary Accession #
Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2[Other Products]
UniProt Related Accession #
Q9P2D1[Other Products]
Molecular Weight
101,085 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Symbol
CHD7??[Similar Products]
NCBI Official Synonym Symbols
CRG; HH5; IS3; KAL5
??[Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD7??[Similar Products]
UniProt Synonym Gene Names
KIAA1416; CHD-7??[Similar Products]
UniProt Entry Name
CHD7_HUMAN
NCBI Summary for CHD7
This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for CHD7
CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and ***** tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.12; Helicase; Nucleolus; DNA-binding
Chromosomal Location of Human Ortholog: 8q12.2
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding
Biological Process: limb development; heart morphogenesis; central nervous system development; olfactory behavior; blood circulation; palate development; positive regulation of multicellular organism growth; ***** walking behavior; olfactory nerve development; female genitalia development; embryonic hindlimb morphogenesis; regulation of growth hormone secretion; regulation of neurogenesis; sensory perception of sound; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; ***** heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; cranial nerve development; semicircular canal morphogenesis; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing
Disease: Charge Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Research Articles on CHD7
1. These data provide additional evidence that CHD7 mutations are a significant cause of semicircular canal atresia in children with full or partial CHARGE syndrome.
Precautions
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Disclaimer
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