ATRX; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); RP5-875J14.1; ATR2; MGC2094; MRXS3; RAD54; RAD54L; SHS; XH2; XNP; ZNF-HX; DNA dependent ATPase and helicase; OTTHUMP00000062079; RAD54 (Saccharomyces cerevisiae); ATRX antibody; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog; S. cerevisiae) antibody; RP5-875J14.1 antibody; ATR2 antibody; MGC2094 antibody; MRXS3 antibody; RAD54 antibody; RAD54L antibody; SHS antibody; XH2 antibody; XNP antibody; ZNF-HX antibody; DNA dependent ATPase and helicase antibody; OTTHUMP00000062079 antibody; RAD54 (Saccharomyces cerevisiae) antibody; X-linked nuclear protein antibody; Zinc finger helicase antibody; alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae) homolog) antibody; helicase 2; X-linked antibody; transcriptional regulator ATRX antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-ATRX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the expected size of 300kDa according to the literature (PMID: 15591283). Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.

151,556 Da

alpha thalassemia/mental retardation syndrome X-linked

transcriptional regulator ATRX

Transcriptional regulator ATRX

RAD54L; XH2; XNP??[Similar Products]

ATRX_HUMAN

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013]

ATRX: a global transcriptional regulator. Belongs to the SNF2 family of proteins, many of which modify gene expression via chromatin remodeling activity. Involved in the developmental silencing of imprinted genes in the brain. Contains one PxVxL motif, which is required for interaction with chromoshadow domains. This motif requires additional residues at -7, -6, +4 and +5 relative to the central V which contact the chromoshadow domain. Constitutive mutations in ATRX are associated with brain, facial, and genital abnormalities, and alpha thalassemia. Acquired mutations in ATRX have been observed in preleukemic conditions. Six alternatively spliced human isoforms have been described.

Protein type: EC 3.6.4.12; Helicase; DNA repair, damage; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: centric heterochromatin; nuclear chromosome, telomeric region; nuclear heterochromatin; nucleus; PML body

Molecular Function: ATP binding; chromatin binding; DNA binding; DNA helicase activity; DNA translocase activity; helicase activity; histone binding; metal ion binding; methylated histone residue binding; protein binding

Biological Process: chromatin remodeling; DNA damage response, signal transduction by p53 class mediator; DNA duplex unwinding; DNA methylation; DNA recombination; DNA repair; DNA replication-independent nucleosome assembly; forebrain development; multicellular organism growth; nucleosome assembly; positive regulation of telomere maintenance; positive regulation of transcription from RNA polymerase II promoter; post-embryonic forelimb morphogenesis; regulation of transcription, DNA-dependent; replication fork processing; Sertoli cell development; spermatogenesis; transcription, DNA-dependent

Disease: Alpha-thalassemia Myelodysplasia Syndrome; Alpha-thalassemia/mental Retardation Syndrome, X-linked; Mental Retardation-hypotonic Facies Syndrome, X-linked, 1

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.