FLRT3; HH21

For Research Use Only. Not for use in diagnostic procedures.

Baculovirus

> 90% by SDS-PAGE

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

1mg/ml (determined by Absorbance at 280nm) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of FLRT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FLRT3, also known as leucine-rich repeat transmembrane protein FLRT3, belongs to the fibronectin leucine rich transmembrane protein (FLRT) family. It contains onefibronectin type-III domain and ten LRR (leucine-rich) repeats and expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. The members of the FLRT family may have a function in cell adhesion and/or receptor signaling. It has been implicated in neurite outgrowth after nerve damage, as a positive regulator of FGF signalling and in homotypic cell adhesion. It may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge. Recombinant human FLRT3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Signal Transduction; Cytoskeleton

SDS-PAGE

57.6kDa (508aa) 70-100KDa (SDS-PAGE under reducing conditions.)[Similar Products]

fibronectin leucine rich transmembrane protein 3

leucine-rich repeat transmembrane protein FLRT3

Leucine-rich repeat transmembrane protein FLRT3

KIAA1469??[Similar Products]

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development ().

Lacy S E., et al. (1999) Genomics. 62:417-426.; Haines B. P., et al. (2006) Dev. Biol. 297:14-25.

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