Product Name
IL-22 BP, Monoclonal Antibody
Popular Item
Full Product Name
Mouse Anti-Human IL-22 BP
Product Synonym Names
IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2
Product Gene Name
anti-IL-22 BP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.12 (137143820..137173648, complement). Location: 6q23.3
3D Structure
ModBase 3D Structure for Q969J5
Purity/Purification
Protein G chromatography
Preparation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-22BP.
Antigen
Recombinant human IL-22BP.
Reconstitution buffer
PBS (sterile)
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Remarks
This antibody was selected for its ability to detect IL22BP.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IL-22 BP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL-22 BP antibody
Interleukin 22 binding protein (IL-22BP), also known as cytokine receptor family (CRF) 2-10, CRF2-X, and IL-22 RA2, is a secreted glycoprotein belonging to the type II cytokine receptor family. IL-22BP antagonizes IL-22 activity by specifically binding IL-22 with high affinity and blocking its interaction with the cell surface IL-22 receptor heteromeric complex composed of IL-22R and IL-10R2 (IL-10 R beta). The highest levels of IL-22BP expression are found in breast, lungs and colon.
Applications Tested/Suitable for anti-IL-22 BP antibody
Western Blot (WB)
Application Notes for anti-IL-22 BP antibody
Western Blot: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for IL-22 BP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443194.1
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NCBI GenBank Nucleotide #
NM_052962.2
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UniProt Primary Accession #
Q969J5
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UniProt Secondary Accession #
Q08AH7; Q6UWM1; Q96A41; Q96QR0[Other Products]
UniProt Related Accession #
Q969J5[Other Products]
NCBI Official Full Name
interleukin-22 receptor subunit alpha-2 isoform 1
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 2
NCBI Official Symbol
IL22RA2??[Similar Products]
NCBI Official Synonym Symbols
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
??[Similar Products]
NCBI Protein Information
interleukin-22 receptor subunit alpha-2; interleukin 22-binding protein; cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-2
UniProt Synonym Protein Names
Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16
UniProt Gene Name
IL22RA2??[Similar Products]
UniProt Synonym Gene Names
IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP??[Similar Products]
UniProt Entry Name
I22R2_HUMAN
NCBI Summary for IL-22 BP
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for IL-22 BP
Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Ref.2 Ref.3 Ref.4Isoform 1 may play a role in establishing and maintaining successful pregnancy. Ref.2 Ref.3 Ref.4
Subcellular location: Secreted Ref.12.
Tissue specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. Ref.1 Ref.4 Ref.11
Sequence similarities: Belongs to the type II cytokine receptor family.Contains 3 fibronectin type-III domains.
Sequence caution: The sequence AAQ89097.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on IL-22 BP
1. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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