Product Name
IL-38 (IL1F10), Recombinant Protein
Popular Item
Full Product Name
IL-38, Recombinant, Human (His) (Interleukin-1 Family Member 10 theta, IL-1F10, FIL1 theta, FKSG75, IL-1HY2, IL1-theta, Interleukin-1 HY2, Interleukin-1 Receptor Antagonist FKSG75)
Product Gene Name
IL1F10 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. Swiss/UniP rot Accession: Q8WWZ1
Chromosome Location
Chromosome: 2; NC_000002.11 (113825547..113833427). Location: 2q13
3D Structure
ModBase 3D Structure for Q8WWZ1
Form/Format
Supplied as a lyophilized powder from 55mM Tris-Cl, pH 8.2, 150mM sodium chloride.
Endotoxin
<1EU/ug protein
Reconstitution
Reconstitute with sterile ddH2O
Preparation and Storage
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the orignal vial after thawing prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of IL1F10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL1F10 recombinant protein
IL-38 (IL-1F10) belongs to the IL-1 family. IL-38 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 binds soluble IL-1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.
Product Categories/Family for IL1F10 recombinant protein
Growth Factors, Cytokines; Growth Factors-Interleukin
NCBI/Uniprot data below describe general gene information for IL1F10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775184.1
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NCBI GenBank Nucleotide #
NM_173161.2
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UniProt Primary Accession #
Q8WWZ1
[Other Products]
UniProt Secondary Accession #
Q53SR9; Q56AT8; Q7RTZ5; Q969H5; Q9BYX1[Other Products]
UniProt Related Accession #
Q8WWZ1[Other Products]
Molecular Weight
~18kD (SDS-PAGE)[Similar Products]
NCBI Official Full Name
interleukin-1 family member 10
NCBI Official Synonym Full Names
interleukin 1 family, member 10 (theta)
NCBI Official Symbol
IL1F10??[Similar Products]
NCBI Official Synonym Symbols
IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
??[Similar Products]
NCBI Protein Information
interleukin-1 family member 10; FIL1 theta; IL-1 theta; interleukin-1 HY2; IL-1F10 (canonical form IL-1F10a); interleukin-1 receptor antagonist FKSG75; interleukin-1 receptor antagonist-like FIL1 theta
UniProt Protein Name
Interleukin-1 family member 10
UniProt Synonym Protein Names
Family of interleukin 1-theta; FIL1 theta; Interleukin-1 HY2; IL-1HY2; Interleukin-1 theta; IL-1 theta; Interleukin-38
Protein Family
Interleukin-1 family
UniProt Gene Name
IL1F10??[Similar Products]
UniProt Synonym Gene Names
FIL1T; IL1HY2; IL38; IL-1F10; FIL1 theta; IL-1HY2; IL-1 theta; IL-38??[Similar Products]
UniProt Entry Name
IL1FA_HUMAN
NCBI Summary for IL1F10
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for IL1F10
IL1F10: Binds soluble IL-1 receptor type 1. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: extracellular space
Molecular Function: interleukin-1 receptor binding; cytokine activity
Biological Process: cytokine and chemokine mediated signaling pathway
Research Articles on IL1F10
1. The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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