Product Name
IL22BP, Polyclonal Antibody
Full Product Name
Human IL22BP Affinity Purified Polyclonal
Product Synonym Names
RAA05512; polyclonal; IL22BP
Product Gene Name
anti-IL22BP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (137464957..137494785, complement). Location: 6q23.3
3D Structure
ModBase 3D Structure for Q969J5
Preparation and Storage
This antibody can be stored in working aliquots at 2C - 8C for one month without detectable loss of activity. The antibody is stable for at least 1 year from date of receipt at -20C.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-IL22BP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IL22BP antibody
Antigen affinity polyclonals
Application Notes for anti-IL22BP antibody
Western Blot Concentration: 0.1-0.2 ug/ml
Western Blot Limit: 0.5ng/lane
ELISA Concentration: 0.5-1.0 ug/ml
ELISA Limit: 2 pg/well
NCBI/Uniprot data below describe general gene information for IL22BP. It may not necessarily be applicable to this product.
NCBI Accession #
AAK85716.1
[Other Products]
UniProt Primary Accession #
Q969J5
[Other Products]
UniProt Secondary Accession #
Q08AH7; Q6UWM1; Q96A41; Q96QR0[Other Products]
UniProt Related Accession #
Q969J5[Other Products]
Molecular Weight
30,550 Da
NCBI Official Full Name
interleukin 22-binding protein CRF2-10S
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 2
NCBI Official Symbol
IL22RA2??[Similar Products]
NCBI Official Synonym Symbols
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
??[Similar Products]
NCBI Protein Information
interleukin-22 receptor subunit alpha-2; interleukin 22-binding protein; cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-2
UniProt Synonym Protein Names
Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16
UniProt Gene Name
IL22RA2??[Similar Products]
UniProt Synonym Gene Names
IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP??[Similar Products]
UniProt Entry Name
I22R2_HUMAN
NCBI Summary for IL22BP
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for IL22BP
IL22RA2: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component: extracellular space; plasma membrane; integral to membrane; cytosol
Molecular Function: interleukin-22 binding; interleukin-22 receptor activity
Biological Process: cytokine and chemokine mediated signaling pathway; regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of inflammatory response
Research Articles on IL22BP
1. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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