Product Name
IL22RA2, Polyclonal Antibody
Full Product Name
IL22RA2, NT (IL22RA2, Interleukin-22 receptor subunit alpha-2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, Cytokine receptor family type 2, soluble 1, Interleukin-22-binding protein, ZcytoR16)
Product Synonym Names
Anti -IL22RA2, NT (IL22RA2, Interleukin-22 receptor subunit alpha-2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, Cytokine receptor family type 2, soluble 1, Interleukin-22-binding protein, ZcytoR16)
Product Gene Name
anti-IL22RA2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (137464957..137494785, complement). Location: 6q23.3
3D Structure
ModBase 3D Structure for Q969J5
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
IL22RA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human IL22RA2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-IL22RA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL22RA2 antibody
The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Product Categories/Family for anti-IL22RA2 antibody
Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-IL22RA2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-IL22RA2 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for IL22RA2. It may not necessarily be applicable to this product.
NCBI Accession #
AAQ89097.1
[Other Products]
UniProt Primary Accession #
Q969J5
[Other Products]
UniProt Secondary Accession #
Q08AH7; Q6UWM1; Q96A41; Q96QR0[Other Products]
UniProt Related Accession #
Q969J5[Other Products]
Molecular Weight
30,550 Da[Similar Products]
NCBI Official Full Name
IL22RA2
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 2
NCBI Official Symbol
IL22RA2??[Similar Products]
NCBI Official Synonym Symbols
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
??[Similar Products]
NCBI Protein Information
interleukin-22 receptor subunit alpha-2; interleukin 22-binding protein; cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-2
UniProt Synonym Protein Names
Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16
Protein Family
Interleukin-22 receptor
UniProt Gene Name
IL22RA2??[Similar Products]
UniProt Synonym Gene Names
IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP??[Similar Products]
UniProt Entry Name
I22R2_HUMAN
NCBI Summary for IL22RA2
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for IL22RA2
IL22RA2: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component: extracellular space; plasma membrane; integral to membrane; cytosol
Molecular Function: interleukin-22 binding; interleukin-22 receptor activity
Biological Process: regulation of tyrosine phosphorylation of Stat3 protein; cytokine and chemokine mediated signaling pathway; negative regulation of inflammatory response
Research Articles on IL22RA2
1. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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