Full Product Name
Human CLCF1 Polyclonal Antibody
Product Synonym Names
BSF3; CLC; NNT1; B-cell-stimulating factor 3; Novel neurotrophin-1; BSF-3; NNT-1
Product Gene Name
anti-CLCF1 antibody
[Similar Products]
Matching Pairs
Antibody: CLCF1 (MBS2898193)
Antigen: Cardiotrophin-like cytokine factor 1 (MBS2889317)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBD9
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human CLCF1 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-CLCF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CLCF1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CLCF1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037378.1
[Other Products]
NCBI GenBank Nucleotide #
NP_037378.1
[Other Products]
UniProt Primary Accession #
Q9UBD9
[Other Products]
UniProt Related Accession #
Q9UBD9[Other Products]
NCBI Official Full Name
cardiotrophin-like cytokine factor 1 isoform 1
NCBI Official Synonym Full Names
cardiotrophin like cytokine factor 1
NCBI Official Symbol
CLCF1??[Similar Products]
NCBI Official Synonym Symbols
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
??[Similar Products]
NCBI Protein Information
cardiotrophin-like cytokine factor 1
UniProt Protein Name
Cardiotrophin-like cytokine factor 1
UniProt Synonym Protein Names
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1
Protein Family
Cardiotrophin-like cytokine factor
UniProt Gene Name
CLCF1??[Similar Products]
UniProt Synonym Gene Names
BSF3; CLC; NNT1; BSF-3; NNT-1??[Similar Products]
UniProt Entry Name
CLCF1_HUMAN
NCBI Summary for CLCF1
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
UniProt Comments for CLCF1
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Apoptosis; Cytokine
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: extracellular region
Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding
Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of astrocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein
Disease: Cold-induced Sweating Syndrome 2
Research Articles on CLCF1
1. CLF-1, based on its for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover.
Precautions
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Disclaimer
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