ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1; ADAMTSL4; TSRC1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-ADAMTSL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.

ELISA (EIA), Immunohistochemistry (IHC)

Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7043888 at dilution 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7043888 at dilution 1:100

118,822 Da

ADAMTS like 4

ADAMTS-like protein 4

ADAMTS-like protein 4

; ADAMTSL-4??[Similar Products]

ATL4_HUMAN

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]

TSRC1: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Defects in ADAMTSL4 are a cause of autosomal recessive isolated ectopia lentis (ARI-EL). ARI-EL is a rare condition characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: endoplasmic reticulum lumen

Molecular Function: protease binding; protein binding

Biological Process: positive regulation of apoptosis

Disease: Ectopia Lentis 2, Isolated, Autosomal Recessive; Ectopia Lentis Et Pupillae

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