Tau tubulin kinase 2, TTBK, SCA11

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist; this antibody will detect only the two largest isoforms.

Affinity chromatography purified via peptide column

PBS containing 0.02% sodium azide.

Store at 4 degree C for three months and -20 degree C, stable for up to one year.

Small volumes of anti-TTBK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 ug/ml.

54,037 Da

tau tubulin kinase 2

tau-tubulin kinase 2

Tau-tubulin kinase 2

KIAA0847??[Similar Products]

TTBK2_HUMAN

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: centriole; extracellular space; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: regulation of cell shape; peptidyl-serine phosphorylation; smoothened signaling pathway; organelle organization and biogenesis; cilium biogenesis

Disease: Spinocerebellar Ataxia 11

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