Product Name
CRALBP, Polyclonal Antibody
Full Product Name
Anti-CRALBP Rabbit pAb
Product Gene Name
anti-CRALBP antibody
[Similar Products]
Product Synonym Gene Name
RLBP1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P12271
Species Reactivity
Mouse, Rat
Specificity
CRALBP Antibody detects endogenous levels of total CRALBP
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human CRALBP
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-CRALBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRALBP antibody
Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors.
Applications Tested/Suitable for anti-CRALBP antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CRALBP antibody
WB: 1:500-1:2000
IP: 1:50
Western Blot (WB) of anti-CRALBP antibody
Western blot analysis of CRALBP expression in mouse eyeball lysate.
NCBI/Uniprot data below describe general gene information for CRALBP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000317.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000326.4
[Other Products]
UniProt Primary Accession #
P12271
[Other Products]
UniProt Secondary Accession #
B2R667[Other Products]
UniProt Related Accession #
P12271[Other Products]
NCBI Official Full Name
retinaldehyde-binding protein 1
NCBI Official Synonym Full Names
retinaldehyde binding protein 1
NCBI Official Symbol
RLBP1??[Similar Products]
NCBI Official Synonym Symbols
CRALBP
??[Similar Products]
NCBI Protein Information
retinaldehyde-binding protein 1
UniProt Protein Name
Retinaldehyde-binding protein 1
UniProt Synonym Protein Names
Cellular retinaldehyde-binding protein
UniProt Gene Name
RLBP1??[Similar Products]
UniProt Synonym Gene Names
CRALBP??[Similar Products]
NCBI Summary for CRALBP
The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]
UniProt Comments for CRALBP
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Research Articles on CRALBP
1. we provide evidence for an allosteric modulation of the enzymatic activity by 11-cis retinoids. This regulation is independent from cellular retinaldehyde-binding protein (CRALBP), the major cis-retinoid binding protein.
Precautions
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Disclaimer
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