Full Product Name
BCOR Antibody
Product Synonym Names
BCL-6 corepressor; BCoR; KIAA1575
Product Gene Name
anti-BCOR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6W2J9
Species Reactivity
Human, Mouse
Specificity
BCOR Antibody detects endogenous levels of BCOR.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human BCOR.
Immunogen Range
1208-1257
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-BCOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BCOR antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-BCOR antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Western Blot (WB) of anti-BCOR antibody
Western blot analysis of the lysates from HeLa cells using BCOR antibody.
NCBI/Uniprot data below describe general gene information for BCOR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116855.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001123383.1
[Other Products]
UniProt Primary Accession #
Q6W2J9
[Other Products]
UniProt Secondary Accession #
Q29RF6; Q6P4B6; Q7Z2K7; Q8TEB4; Q96DB3; Q9H232; Q9H233; Q9HCJ7; Q9NXF2; D3DWB3; D3DWB4[Other Products]
UniProt Related Accession #
Q6W2J9[Other Products]
NCBI Official Full Name
BCL-6 corepressor isoform a
NCBI Official Synonym Full Names
BCL6 corepressor
NCBI Official Symbol
BCOR??[Similar Products]
NCBI Official Synonym Symbols
MAA2; ANOP2; MCOPS2
??[Similar Products]
NCBI Protein Information
BCL-6 corepressor
UniProt Protein Name
BCL-6 corepressor
Protein Family
BCL-6 corepressor
UniProt Gene Name
BCOR??[Similar Products]
UniProt Synonym Gene Names
KIAA1575; BCoR??[Similar Products]
NCBI Summary for BCOR
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
UniProt Comments for BCOR
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in ***** stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Research Articles on BCOR
1. Immunohistochemistry for either CCNB3 or BCOR is not completely sensitive and specific in undifferentiated sarcoma with BCOR-CCNB3 fusion.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
