G-protein coupled receptor 56 [Precursor]; Protein TM7XN1; TM7LN4; TM7XN1; UNQ540/PRO1083

For Research Use Only. Not for use in diagnostic procedures.

GPR56 antibody detects endogenous levels of total GPR56 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-GPR56 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:20000

Peptide-+ Western blot analysis of extracts from K562 cells, using GPR56 antibody. Immunofluorescence analysis of MCF-7cells, using GPR56 antibody.

58,042 Da

adhesion G protein-coupled receptor G1

adhesion G-protein coupled receptor G1

Adhesion G-protein coupled receptor G1

ADGRG1 NT; GPR56 NT; GPR56(N); ADGRG1 CT; GPR56 CT; GPR56(C); GPR56 7TM??[Similar Products]

This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development ().

Liu M., Genomics 55:296-305(1999). Zendman A.J.W., FEBS Lett. 446:292-298(1999). Clark H.F., Genome Res. 13:2265-2270(2003).

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