Full Product Name
GPR56 Antibody
Product Gene Name
anti-GPR56 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y653
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-GPR56 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GPR56 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GPR56 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for GPR56. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001139242.1
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NCBI GenBank Nucleotide #
NM_001145770.2
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UniProt Primary Accession #
Q9Y653
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UniProt Secondary Accession #
O95966; Q6ZMP1; Q8NGB3; Q96HB4; A6NIT7; A6NJV9; B0M0K4; B4DR54[Other Products]
UniProt Related Accession #
Q9Y653[Other Products]
Molecular Weight
58,042 Da
NCBI Official Full Name
adhesion G-protein coupled receptor G1 isoform b
NCBI Official Synonym Full Names
adhesion G protein-coupled receptor G1
NCBI Official Symbol
ADGRG1??[Similar Products]
NCBI Official Synonym Symbols
BFPP; BPPR; GPR56; TM7LN4; TM7XN1
??[Similar Products]
NCBI Protein Information
adhesion G-protein coupled receptor G1
UniProt Protein Name
Adhesion G-protein coupled receptor G1
UniProt Synonym Protein Names
G-protein coupled receptor 56; Protein TM7XN1
UniProt Gene Name
ADGRG1??[Similar Products]
UniProt Synonym Gene Names
ADGRG1 NT; GPR56 NT; GPR56(N); ADGRG1 CT; GPR56 CT; GPR56(C); GPR56 7TM??[Similar Products]
NCBI Summary for GPR56
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for GPR56
GPR56: Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: integral to membrane; integral to plasma membrane
Molecular Function: collagen binding; extracellular matrix binding; G-protein coupled receptor activity; heparin binding
Biological Process: angiogenesis; brain development; cell adhesion; cell migration; cell-cell signaling; cerebral cortex radial glia guided migration; layer formation in the cerebral cortex; negative regulation of cell proliferation; positive regulation of cell adhesion; positive regulation of Rho protein signal transduction; Rho protein signal transduction
Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive
Research Articles on GPR56
1. High GPR56 expression was significantly associated with high-risk genetic subgroups and poor outcome in patients with acute myeloid leukemia and identifies cancer stem cells with high repopulating potential.
Precautions
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Disclaimer
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