Product Name
Amyloid beta A4 precursor protein-binding family A member 2 (Apba2), Recombinant Protein
Full Product Name
Recombinant Rat Amyloid beta A4 precursor protein-binding family A member 2 (Apba2)
Product Gene Name
Apba2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-750aa, Full length protein
Sequence
MAHRKRQSTA SSMLDHRARP GPIPHDQEPE NEDTELPLES YVPTGLELGT LRPDSPTPEE QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY IRYCPEDDSY LEGMDCNGEE YLAHGAHPVD TDECQEAVED WTDSVGPHTH SHGAENSQEY PDSHLPIPED DPTVLEVHDQ EEDGHYCPSK ESYQDYYPPE TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM TSITSASEAS PEHMPELDPG DSTEACSPSD TGRGPSRQEA RPKSLNLPPE VKHSGDPQRG LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA SFPSFVAVPG PCEPEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE AVSRVKRMQK AAKIKKKANS EGDAQTLTEV DLFISTQRIK VLNADTQETM MDHALRTISY IADIGNIVVL MARRRMPRSA SQDCIETTPG AQEGKKQYKM ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS QKEYSDIINT QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL NIVSCPPVTT VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATAHEKIVQA LSNSVGEIHM KTMPAAMFRL LTGQETPLYI
3D Structure
ModBase 3D Structure for O35431
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Apba2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Apba2 recombinant protein
This protein is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Apba2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_113968.1
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NCBI GenBank Nucleotide #
NM_031780.1
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UniProt Primary Accession #
O35431
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UniProt Related Accession #
O35431[Other Products]
Molecular Weight
82,850 Da
NCBI Official Full Name
amyloid-beta A4 protein-binding family A member 2
NCBI Official Synonym Full Names
amyloid beta precursor protein binding family A member 2
NCBI Official Symbol
Apba2??[Similar Products]
NCBI Official Synonym Symbols
Mint2
??[Similar Products]
NCBI Protein Information
amyloid-beta A4 precursor protein-binding family A member 2
UniProt Protein Name
Amyloid-beta A4 precursor protein-binding family A member 2
UniProt Synonym Protein Names
Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2
Protein Family
Amyloid beta A4 precursor protein-binding family
UniProt Gene Name
Apba2??[Similar Products]
UniProt Synonym Gene Names
Mint2; Mint-2??[Similar Products]
NCBI Summary for Apba2
component of multimeric complex containing component of multimeric complex containing Munc18-1 and syntaxin; binds PIP and PIP2; may mediate synaptic vesicle docking/fusion [RGD, Feb 2006]
UniProt Comments for Apba2
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Research Articles on Apba2
1. These data suggest that Mint2 may play more important role in spinal cord than the other two family members.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
