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GATA binding protein 2, Polyclonal Antibody

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產(chǎn)品名稱: GATA binding protein 2, Polyclonal Antibody
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GATA binding protein 2, Polyclonal Antibody


GATA binding protein 2, Polyclonal Antibody  的詳細(xì)介紹
Product Name

GATA binding protein 2 (GATA2), Polyclonal Antibody

Full Product Name

Rabbit anti-human GATA binding protein 2 polyclonal Antibody

Product Synonym Names
GATA binding protein 2; GATA2; FLJ45948; MGC2306; NFE1B
Product Gene Name

anti-GATA2 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
614286
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human GATA2
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16044 / sc-1235 / sc-9008
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GATA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-GATA2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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NCBI/Uniprot data below describe general gene information for GATA2. It may not necessarily be applicable to this product.
NCBI GI #
30410997
NCBI GeneID
2624
NCBI Accession #
AAH51342.1 [Other Products]
UniProt Secondary Accession #
Q53YE0; Q96BH0; Q96BH8; Q9BUJ6; D3DNB3[Other Products]
UniProt Related Accession #
P23769[Other Products]
Molecular Weight
49,106 Da[Similar Products]
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NCBI Official Full Name
GATA binding protein 2
NCBI Official Synonym Full Names
GATA binding protein 2
NCBI Official Symbol
GATA2??[Similar Products]
NCBI Official Synonym Symbols
DCML; IMD21; NFE1B; MONOMAC
??[Similar Products]
NCBI Protein Information
endothelial transcription factor GATA-2
UniProt Protein Name
Endothelial transcription factor GATA-2
UniProt Synonym Protein Names
GATA-binding protein 2
Protein Family
GATA-binding factor
UniProt Gene Name
GATA2??[Similar Products]
UniProt Entry Name
GATA2_HUMAN
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NCBI Summary for GATA2
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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UniProt Comments for GATA2
GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; protein complex

Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor binding; transcription factor activity

Biological Process: inner ear morphogenesis; embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of erythrocyte differentiation; cell maturation; regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; cell differentiation in hindbrain; negative regulation of macrophage differentiation; pituitary gland development; homeostasis of number of cells within a tissue; commitment of a neuronal cell to a specific type of neuron in the forebrain; ventral spinal cord interneuron differentiation; positive regulation of phagocytosis; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of megakaryocyte differentiation; blood coagulation; urogenital system development; central nervous system neuron development

Disease: Lymphedema, Primary, With Myelodysplasia; Immunodeficiency 21; Myelodysplastic Syndrome
Research Articles on GATA2
1. low-GATA2-expressing specimens (GATA2(low)) exhibit allele-specific expression (ASE) (skewing) in more than half of acute myeloid leukemia patients.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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