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14-3-3 protein beta/alpha, Polyclonal Antibody

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產(chǎn)品名稱: 14-3-3 protein beta/alpha, Polyclonal Antibody
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14-3-3 protein beta/alpha, Polyclonal Antibody


14-3-3 protein beta/alpha, Polyclonal Antibody  的詳細(xì)介紹
Product Name

14-3-3 protein beta/alpha (YWHAB), Polyclonal Antibody

Full Product Name

Rabbit anti-human 14-3-3 protein beta/alpha polyclonal Antibody, Biotin conjugated

Product Synonym Names
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; 14-3-3 protein beta/alpha; N-terminally processed
Product Gene Name

anti-YWHAB antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
601289
3D Structure
ModBase 3D Structure for P31946
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Biotin
Immunogen
Recombinant human 14-3-3 protein beta/alpha protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17288 / sc-13959 / sc-629 / sc-628
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-YWHAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-YWHAB antibody
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
Applications Tested/Suitable for anti-YWHAB antibody
ELISA (EIA)

Western Blot (WB) of anti-YWHAB antibody
All lanes: 14-3-3 protein beta/alpha antibody at 2 ug/ml Lane 1: 293T whole cell lysate Lane 2: EC109 whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 27 kDa Observed band size:27 kDa Immunohistochemistry
anti-YWHAB antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-YWHAB antibody
Immunohistochemistry of paraffin-embeded human kidney at dilution of 1:50
anti-YWHAB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for YWHAB. It may not necessarily be applicable to this product.
NCBI GI #
4507949
NCBI GeneID
7529
NCBI Accession #
NP_003395.1 [Other Products]
NCBI GenBank Nucleotide #
NM_003404.4 [Other Products]
UniProt Primary Accession #
P31946 [Other Products]
UniProt Secondary Accession #
A8K9K2; E1P616[Other Products]
UniProt Related Accession #
P31946[Other Products]
Molecular Weight
27,850 Da[Similar Products]
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NCBI Official Full Name
14-3-3 protein beta/alpha
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Official Symbol
YWHAB??[Similar Products]
NCBI Official Synonym Symbols
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
??[Similar Products]
NCBI Protein Information
14-3-3 protein beta/alpha
UniProt Protein Name
14-3-3 protein beta/alpha
UniProt Synonym Protein Names
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
Protein Family
14-3-3 protein
UniProt Gene Name
YWHAB??[Similar Products]
UniProt Synonym Gene Names
KCIP-1??[Similar Products]
UniProt Entry Name
1433B_HUMAN
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NCBI Summary for YWHAB
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for YWHAB
14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; focal adhesion; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; transcriptional repressor complex

Molecular Function: enzyme binding; histone deacetylase binding; phosphoprotein binding; phosphoserine binding; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; transcription corepressor activity

Biological Process: activation of MAPKK activity; apoptosis; axon guidance; cytoplasmic sequestering of protein; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of protein amino acid dephosphorylation; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of catalytic activity; programmed cell death; protein heterooligomerization; protein targeting; Ras protein signal transduction; regulation of mRNA stability; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; viral reproduction
Research Articles on YWHAB
1. These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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