Anti -14-3-3 theta (14-3-3 tau)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (9724106..9771106, complement). Location: 2p25.1

Monoclonal

IgG1

5J20

Mouse

Recognizes human 14-3-3 theta/tau. Does not crossreact with 14-3-3 zeta. 14-3-3 theta/tau is expressed by brain tissue and cells of the male germ line. Species Crossreactivity: mouse, rat and bovine.

Purified
Purified

Supplied as a liquid in 20mM sodium phosphate, 150mM sodium chloride, pH 7.5, 0.08% sodium azide, 50% glycerol.

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-YWHAQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The 14-3-3 proteins are a family of homologous, evolutionarily conserved, acidic proteins expressed in all eukaryotes, with molecular masses ranging from 28-33kD. To date, seven different 14-3-3 isoforms have been identified in mammals, each encoded by a distinct gene. The expression of 14-3-3 isoforms is tissue specific and differentially regulated. The 14-3-3 proteins assemble into stable homo- and heterodimers, which modulate signaling cascades by binding to phosphorylated serine or threonine residues of target proteins. In addition to a phosphorylated serine or phohsphorylated threonine residue, 14-3-3 protein binding also requires an arginine located at position -3 or -4. The 14-3-3 proteins affect signaling in several manners, including: interfering with protein/protein interactions (example: 14-3-3's interference

Antibodies; Abs to 14-3-3

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

Suitable for use in Western Blot and Immunoprecipitation of both the native and denatured forms of the protein.

27,764 Da[Similar Products]

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

14-3-3 protein theta; protein tau; 14-3-3 protein tau; OTTHUMP00000015730; OTTHUMP00000165887; 14-3-3 protein T-cell

14-3-3 protein theta

1433T_HUMAN

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq]

14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; cytoplasm; cytosol

Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding

Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting

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