Anti -CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (111260926..111371206). Location: 3q13.13-q13.2

Monoclonal

IgG1

9G159

Mouse

Recognizes human CD96, also known as T cell-activated increased late expression (Tactile). Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.

Purified

Supplied as a liquid in PBS, 0.1% BSA.

0.1mg/ml (lot specific)

May be stored at 4 degree C for short-term only. Aliquot to avoid repeatedd freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CD96 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.

Antibodies; Abs to CD Markers

Flow Cytometry (FC/FACS)

Suitable for use in Flow Cytometry and Funcional Studies. Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.
Dilution: Flow Cytometry: 1:50
Functional Studies: Make according to the amounts of CD96 to be inactivated. Optimal dilutions to be determined by the researcher.

65,634 Da[Similar Products]

CD96 molecule

T-cell surface protein tactile; CD96 antigen; OTTHUMP00000214642; OTTHUMP00000214643; OTTHUMP00000214645; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein

T-cell surface protein tactile

TACT_HUMAN

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

CD96: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Defects in CD96 are a cause of C syndrome (CSYN); also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.13-q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: regulation of immune response; immune response; cell adhesion

Disease: C Syndrome

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